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| 27.11.2021 | 14:30 | Excelsior '31 | - | ACV Assen | 3:0 (1:0) | |
| 14:30 | Harkemase Boys | - | Sparta Nijkerk | 2:3 (2:1) | ||
| 14:45 | AFC Ajax Zaterdag | - | VVOG Harderwijk | 3:6 (2:3) | ||
| 15:00 | Sportlust '46 | - | HSV Hoek | 2:1 (2:1) | ||
| 15:00 | Ter Leede | - | SteDoCo | 3:1 (3:0) | ||
| 17:00 | VV Sint Bavo | - | ODIN '59 | 1:2 (0:1) | ||
| 04.12.2021 | 13:30 | BVV Barendrecht | - | DVS'33 | 2:2 (0:1) | |
| 06.02.2022 | 14:30 | VV GOES | - | FC Lisse | 1:4 (1:2) | |
| 08.03.2022 | 20:00 | VV Staphorst | - | VV DOVO Veenendaal | 2:1 (2:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sportlust '46 | 14 | 9 | 2 | 3 | 31:18 | 13 | 29 |
| 2 |
|
FC Lisse | 14 | 9 | 2 | 3 | 29:16 | 13 | 29 |
| 3 |
|
Sparta Nijkerk | 14 | 9 | 2 | 3 | 27:15 | 12 | 29 |
| 4 |
|
Excelsior '31 | 14 | 8 | 2 | 4 | 29:17 | 12 | 26 |
| 5 |
|
Harkemase Boys | 14 | 6 | 4 | 4 | 31:24 | 7 | 22 |
| 6 |
|
VV Staphorst | 14 | 6 | 4 | 4 | 21:18 | 3 | 22 |
| 7 |
|
DVS'33 | 14 | 6 | 3 | 5 | 21:16 | 5 | 21 |
| 8 |
|
Ter Leede | 14 | 6 | 3 | 5 | 17:21 | -4 | 21 |
| 9 |
|
SteDoCo | 14 | 5 | 4 | 5 | 22:20 | 2 | 19 |
| 10 |
|
BVV Barendrecht | 14 | 4 | 6 | 4 | 26:24 | 2 | 18 |
| 11 |
|
HSV Hoek | 14 | 5 | 3 | 6 | 22:21 | 1 | 18 |
| 12 |
|
ACV Assen | 14 | 5 | 2 | 7 | 19:21 | -2 | 17 |
| 13 |
|
AFC Ajax Zaterdag | 14 | 5 | 2 | 7 | 18:28 | -10 | 17 |
| 14 |
|
ODIN '59 | 14 | 4 | 3 | 7 | 18:29 | -11 | 15 |
| 15 |
|
VV DOVO Veenendaal | 14 | 3 | 4 | 7 | 14:22 | -8 | 13 |
| 16 |
|
VVOG Harderwijk | 14 | 3 | 4 | 7 | 26:37 | -11 | 13 |
| 17 |
|
VV Sint Bavo | 14 | 2 | 4 | 8 | 16:28 | -12 | 10 |
| 18 |
|
VV GOES | 14 | 1 | 6 | 7 | 20:32 | -12 | 9 |
| Promotion | |
| Relégation | |
| Relégation |
