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| H (Match allé) | UANL Tigres | - | Cruz Azul | 0:0 (0:0) | ||
| R (match retour) | Cruz Azul | - | UANL Tigres | 0:0 (0:0) | ||
| H (Match allé): 24.11.2021 16:00 | R (match retour): 27.11.2021 16:00 | |||||
| H (Match allé) | Atlas Guadalajara | - | Santos Laguna | 0:1 (0:1) | ||
| R (match retour) | Santos Laguna | - | Atlas Guadalajara | 0:1 (0:1) | ||
| H (Match allé): 25.11.2021 16:00 | R (match retour): 28.11.2021 18:00 | |||||
