 |
 |
|
| H (Match allé) | Cruz Azul | - | Santos Laguna | 2:1 (0:0) | ||
| R (match retour) | Santos Laguna | - | Cruz Azul | 3:0 (2:0) | ||
| H (Match allé): 02.12.2021 18:00 | R (match retour): 05.12.2021 18:00 | vainqueur: Santos Laguna | ||||
|
|
|
| H (Match allé) | Cruz Azul | - | Santos Laguna | 2:1 (0:0) | ||
| R (match retour) | Santos Laguna | - | Cruz Azul | 3:0 (2:0) | ||
| H (Match allé): 02.12.2021 18:00 | R (match retour): 05.12.2021 18:00 | vainqueur: Santos Laguna | ||||
