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| H (Match allé) | Atlético Cearense - CE | - | Campinense - PB | 1:1 (0:0) | ||
| R (match retour) | Campinense - PB | - | Atlético Cearense - CE | 3:1 (1:1) | ||
| H (Match allé): 23.10.2021 20:00 | R (match retour): 30.10.2021 21:00 | vainqueur: Campinense - PB | ||||
| H (Match allé) | Aparecidense - GO | - | ABC - RN | 4:2 (1:1) | ||
| R (match retour) | ABC - RN | - | Aparecidense - GO | 1:0 (1:0) | ||
| H (Match allé): 24.10.2021 21:00 | R (match retour): 31.10.2021 20:00 | vainqueur: Aparecidense - GO | ||||
