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| H (Match allé) | KS Besëlidhja Lezhë | - | FK Partizani | 0:1 | ||
| R (match retour) | FK Partizani | - | KS Besëlidhja Lezhë | 2:0 (0:0) | ||
| H (Match allé): 03.11.2021 14:00 | R (match retour): 17.11.2021 13:30 | vainqueur: FK Partizani | ||||
| H (Match allé) | KS Korabi Peshkopi | - | KF Teuta Durrës | 0:1 | ||
| R (match retour) | KF Teuta Durrës | - | KS Korabi Peshkopi | 2:0 (1:0) | ||
| H (Match allé): 03.11.2021 14:00 | R (match retour): 17.11.2021 13:30 | vainqueur: KF Teuta Durrës | ||||
| H (Match allé) | KF Bylis Ballsh | - | KF Skënderbeu | 1:1 | ||
| R (match retour) | KF Skënderbeu | - | KF Bylis Ballsh | 4:3 (2:1, 2:2, 2:2) tab | ||
| H (Match allé): 03.11.2021 14:00 | R (match retour): 17.11.2021 13:30 | vainqueur: KF Skënderbeu | ||||
| H (Match allé) | KS Pogradeci | - | FK Vllaznia | 0:2 | ||
| R (match retour) | FK Vllaznia | - | KS Pogradeci | 6:1 (6:0) | ||
| H (Match allé): 03.11.2021 14:00 | R (match retour): 17.11.2021 13:30 | vainqueur: FK Vllaznia | ||||
| H (Match allé) | FK Tomori Berat | - | KF Laçi | 0:1 | ||
| R (match retour) | KF Laçi | - | FK Tomori Berat | 1:1 (0:1) | ||
| H (Match allé): 03.11.2021 14:00 | R (match retour): 17.11.2021 13:30 | vainqueur: KF Laçi | ||||
| H (Match allé) | Flamurtari Vlorë | - | KS Kastrioti | 0:0 | ||
| R (match retour) | KS Kastrioti | - | Flamurtari Vlorë | 2:4 (1:1) | ||
| H (Match allé): 03.11.2021 14:00 | R (match retour): 17.11.2021 13:30 | vainqueur: Flamurtari Vlorë | ||||
| H (Match allé) | Egnatia Rrogozhine | - | FK Kukësi | 3:1 | ||
| R (match retour) | FK Kukësi | - | Egnatia Rrogozhine | 1:0 (1:0) | ||
| H (Match allé): 03.11.2021 14:00 | R (match retour): 17.11.2021 13:30 | vainqueur: Egnatia Rrogozhine | ||||
| H (Match allé) | Dinamo Tiranë | - | KF Tiranë | 2:0 | ||
| R (match retour) | KF Tiranë | - | Dinamo Tiranë | 7:8 (1:0, 2:0, 2:0) tab | ||
| H (Match allé): 03.11.2021 16:45 | R (match retour): 18.11.2021 19:45 | vainqueur: Dinamo Tiranë | ||||
