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| H (Match allé) | Flamurtari Vlorë | - | FK Vllaznia | 1:2 | ||
| R (match retour) | FK Vllaznia | - | Flamurtari Vlorë | 1:0 | ||
| H (Match allé): 26.01.2022 13:45 | R (match retour): 10.02.2022 13:45 | vainqueur: FK Vllaznia | ||||
| H (Match allé) | Egnatia Rrogozhine | - | KF Laçi | 1:1 | ||
| R (match retour) | KF Laçi | - | Egnatia Rrogozhine | 3:2 tab | ||
| H (Match allé): 26.01.2022 13:45 | R (match retour): 10.02.2022 13:45 | vainqueur: KF Laçi | ||||
| H (Match allé) | KF Skënderbeu | - | KF Teuta Durrës | 0:1 | ||
| R (match retour) | KF Teuta Durrës | - | KF Skënderbeu | 1:0 (1:0) | ||
| H (Match allé): 27.01.2022 14:25 | R (match retour): 09.02.2022 16:45 | vainqueur: KF Teuta Durrës | ||||
| H (Match allé) | Dinamo Tiranë | - | FK Partizani | 1:1 | ||
| R (match retour) | FK Partizani | - | Dinamo Tiranë | 1:0 | ||
| H (Match allé): 27.01.2022 16:45 | R (match retour): 10.02.2022 18:00 | vainqueur: FK Partizani | ||||
