 |
 |
| Quarts de finale | ||||||
|---|---|---|---|---|---|---|
| 04.05.2022 | 16:00 | Deportivo Toluca | - | CF América | 0:1 (0:0) | |
| 05.05.2022 | 16:00 | Deportivo Guadalajara | - | Club Tijuana | 0:2 (0:1) | |
| 18:00 | Santos Laguna | - | Club León | 1:0 (0:0) | ||
| 18:00 | UANL Tigres | - | CF Pachuca | 4:2 (2:0) | ||
| 07.05.2022 | 16:30 | CF América | - | Deportivo Toluca | 4:0 (1:0) | |
| 08.05.2022 | 16:00 | Club León | - | Santos Laguna | 5:2 (2:0) | |
| 19:00 | CF Pachuca | - | UANL Tigres | 1:0 (1:0) | ||
| 09.05.2022 | 04:00 | Club Tijuana | - | Deportivo Guadalajara | 1:0 (1:0) | |
| Demi-finales | ||||||
| 12.05.2022 | 04:00 | Club Tijuana | - | CF América | 1:0 (0:0) | |
| 18:00 | UANL Tigres | - | Club León | 1:0 (1:0) | ||
| 14.05.2022 | 16:00 | CF América | - | Club Tijuana | 1:0 (0:0) | |
| 15.05.2022 | 16:00 | Club León | - | UANL Tigres | 3:3 (1:1) | |
| Finale | ||||||
| 19.05.2022 | 02:00 | UANL Tigres | - | CF América | 0:2 (0:1) | |
| 21.05.2022 | 17:00 | CF América | - | UANL Tigres | 3:1 (1:0) | |
