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| Reserva | 12.03.2021 | Rosario Central II | - | Arsenal de Sarandí II | 4:0 | ??? |
| Reserva | 09.04.2021 | Rosario Central II | - | Banfield II | 1:1 | ??? |
| Reserva | 23.04.2021 | Rosario Central II | - | Estudiantes II | 1:3 | ??? |
| Reserva | 23.07.2021 | Rosario Central II | - | Vélez Sarsfield II | 3:0 | ??? |
| Reserva | 30.07.2021 | Rosario Central II | - | Aldosivi II | 4:1 | ??? |
| Reserva | 13.08.2021 | Rosario Central II | - | Independiente II | 3:1 | ??? |
| Reserva | 24.08.2021 | Rosario Central II | - | Arsenal de Sarandí II | 4:0 | ??? |
| Reserva | 03.09.2021 | Rosario Central II | - | Boca Juniors II | 1:3 | ??? |
| Reserva | 17.09.2021 | Rosario Central II | - | San Lorenzo II | 1:2 | ??? |
| Reserva | 01.10.2021 | Rosario Central II | - | Argentinos Juniors II | 0:2 | ??? |
| Reserva | 13.10.2021 | Rosario Central II | - | Patronato de Paraná II | 2:1 | ??? |
| Reserva | 24.10.2021 | Rosario Central II | - | Racing Club II | 1:2 | ??? |
| Reserva | 20.11.2021 | Rosario Central II | - | Atlético Tucumán II | 4:1 | ??? |
| Reserva | 28.11.2021 | Rosario Central II | - | River Plate II | 2:0 | ??? |
Argentine