| 5. Journée | 28.08.2021 | East Fife FC | - | Peterhead FC | 3:0 | ||||
| 7. Journée | 18.09.2021 | Airdrieonians FC | - | East Fife FC | 3:0 | ||||
| 14. Journée | 13.11.2021 | East Fife FC | - | Airdrieonians FC | 0:1 | ||||
| 15. Journée | 20.11.2021 | Clyde FC | - | East Fife FC | 3:1 | ||||
| 16. Journée | 04.12.2021 | East Fife FC | - | Alloa Athletic | 1:1 | ||||
| 25. Journée | 12.02.2022 | Alloa Athletic | - | East Fife FC | 1:3 | ||||
| 26. Journée | 19.02.2022 | East Fife FC | - | Queen's Park FC | 1:1 | ||||
| 27. Journée | 26.02.2022 | Falkirk FC | - | East Fife FC | 3:1 | ||||
| 28. Journée | 05.03.2022 | Montrose FC | - | East Fife FC | 0:0 | ||||
| 29. Journée | 12.03.2022 | East Fife FC | - | Dumbarton FC | 2:0 | ||||
| 31. Journée | 26.03.2022 | East Fife FC | - | Alloa Athletic | 0:3 | ||||
| 32. Journée | 02.04.2022 | East Fife FC | - | Airdrieonians FC | 0:2 |  |
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| 33. Journée | 09.04.2022 | Queen's Park FC | - | East Fife FC | 1:0 | ||||
| 34. Journée | 16.04.2022 | East Fife FC | - | Falkirk FC | 1:3 |
Écosse