| 3. Journée | 08.05.2022 | FC Tulsa | - | Detroit City FC | 3:1 |  |
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| 3. Journée | 15.05.2022 | Detroit City FC | - | Loudoun United | 4:2 | ||||
| 3. Journée | 19.05.2022 | Miami FC | - | Detroit City FC | 1:1 | ||||
| 3. Journée | 22.05.2022 | Detroit City FC | - | Atlanta United II | 3:1 | |
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| 4. Journée | 05.06.2022 | Pittsburgh Riverhounds | - | Detroit City FC | 1:1 | ||||
| 4. Journée | 12.06.2022 | Detroit City FC | - | Sacramento Republic | 0:2 | |
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| 4. Journée | 18.06.2022 | Detroit City FC | - | El Paso Locomotive | 1:1 | ||||
| 5. Journée | 03.07.2022 | Las Vegas Lights FC | - | Detroit City FC | 0:1 | ||||
| 5. Journée | 07.07.2022 | Detroit City FC | - | Hartford Athletic | 1:1 | ||||
| 5. Journée | 17.07.2022 | Monterey Bay FC | - | Detroit City FC | 0:0 | ||||
| 5. Journée | 24.07.2022 | Detroit City FC | - | New Mexico United | 2:2 | ||||
| 6. Journée | 07.08.2022 | Tampa Bay Rowdies | - | Detroit City FC | 1:0 | ||||
| 7. Journée | 22.09.2022 | New York RB II | - | Detroit City FC | 0:0 | ||||
| 8. Journée | 06.10.2022 | Louisville City FC | - | Detroit City FC | 2:1 | ||||
| 8. Journée | 15.10.2022 | Detroit City FC | - | Miami FC | 0:1 |
Canada
France