| 12. Journée | 30.10.2021 | FC Metz | - | AS Saint-Étienne | 1:1 | ||||
| 13. Journée | 07.11.2021 | AS Saint-Étienne | - | Clermont Foot 63 | 3:2 | ||||
| 18. Journée | 11.12.2021 | Stade de Reims | - | AS Saint-Étienne | 2:0 | ||||
| 19. Journée | 22.12.2021 | AS Saint-Étienne | - | FC Nantes | 0:1 | ||||
| 21. Journée | 15.01.2022 | AS Saint-Étienne | - | RC Lens | 1:2 |  |
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| 22. Journée | 21.01.2022 | Olympique Lyonnais | - | AS Saint-Étienne | 1:0 | ||||
| 30. Journée | 03.04.2022 | AS Saint-Étienne | - | Olympique Marseille | 2:4 | ||||
| 31. Journée | 08.04.2022 | FC Lorient | - | AS Saint-Étienne | 6:2 | ||||
| 32. Journée | 16.04.2022 | AS Saint-Étienne | - | Stade Brestois 29 | 2:1 | ||||
| 33. Journée | 20.04.2022 | Girondins Bordeaux | - | AS Saint-Étienne | 2:2 | ||||
| 34. Journée | 23.04.2022 | AS Saint-Étienne | - | AS Monaco | 1:4 | ||||
| 35. Journée | 30.04.2022 | Stade Rennais | - | AS Saint-Étienne | 2:0 | ||||
| 36. Journée | 11.05.2022 | OGC Nice | - | AS Saint-Étienne | 4:2 |
Brésil