| tour des 16 | 24.02.2022 | Pumas UNAM | - | Deportivo Saprissa | 4:1 | ||||
| Quarts de finale | 10.03.2022 | New England Revolution | - | Pumas UNAM | 3:0 | ||||
| Quarts de finale | 17.03.2022 | Pumas UNAM | - | New England Revolution | 3:0 tab | ||||
| Demi-finales | 06.04.2022 | Pumas UNAM | - | Cruz Azul | 2:1 |  |
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| Demi-finales | 13.04.2022 | Cruz Azul | - | Pumas UNAM | 0:0 | ||||
| Finale | 28.04.2022 | Pumas UNAM | - | Seattle Sounders | 2:2 | ||||
| Finale | 05.05.2022 | Seattle Sounders | - | Pumas UNAM | 3:0 |
Brésil