| 1. Journée | 26.02.2022 | Los Angeles FC | - | Colorado Rapids | 3:0 | ||||
| 2. Journée | 06.03.2022 | Colorado Rapids | - | Atlanta United FC | 3:0 |  |
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| 2. Journée | 13.03.2022 | Colorado Rapids | - | Sporting Kansas City | 2:0 | ||||
| 2. Journée | 20.03.2022 | Houston Dynamo | - | Colorado Rapids | 1:1 | |
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| 3. Journée | 03.04.2022 | Colorado Rapids | - | Real Salt Lake | 1:1 | ||||
| 3. Journée | 10.04.2022 | FC Dallas | - | Colorado Rapids | 3:1 | ||||
| 3. Journée | 17.04.2022 | Minnesota United FC | - | Colorado Rapids | 3:1 | ||||
| 3. Journée | 24.04.2022 | Colorado Rapids | - | Charlotte FC | 0:0 | ||||
| 4. Journée | 01.05.2022 | Colorado Rapids | - | Portland Timbers | 2:0 | |
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| 4. Journée | 08.05.2022 | San Jose Earthquakes | - | Colorado Rapids | 1:0 | ||||
| 4. Journée | 14.05.2022 | Colorado Rapids | - | Los Angeles FC | 2:0 | ||||
| 4. Journée | 19.05.2022 | Sporting Kansas City | - | Colorado Rapids | 2:1 |  |
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| 4. Journée | 29.05.2022 | Colorado Rapids | - | Nashville SC | 1:3 | ||||
| 5. Journée | 19.06.2022 | New York City FC | - | Colorado Rapids | 1:1 | ||||
| 5. Journée | 26.06.2022 | Portland Timbers | - | Colorado Rapids | 3:0 | ||||
| 6. Journée | 05.07.2022 | Colorado Rapids | - | Austin FC | 2:3 |
États-Unis