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| 20.09.2022 | 20:45 | Connah's Quay Nomads | - | Holywell Town | 1:0 (0:0) | |
| 20:45 | Caernarfon Town | - | Bala Town | 1:4 (0:2) | ||
| 20:45 | Buckley Town | - | Gresford Athletic | 7:8 (1:1, 2:2) tab | ||
| 20:45 | Afan Lido FC | - | Pontypridd United | 2:0 (0:0) | ||
| 20:45 | Penybont FC | - | Ammanford AFC | 1:2 (0:1) | ||
| 20:45 | Taff's Well AFC | - | Haverfordwest County | 4:3 (1:0, 1:1) tab | ||
| 20:45 | Cardiff Metropolitan | - | Aberystwyth Town | 5:3 (1:2, 2:2) tab | ||
| 21.09.2022 | 20:45 | Ruthin Town | - | Flint Town United | 1:3 (0:2) |
