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| 05.11.2021 | 18:00 | Çaykur Rizespor | - | Alanyaspor | 2:0 (1:0) | |
| 18:00 | Gaziantep FK | - | Kasımpaşa SK | 2:0 (1:0) | ||
| 06.11.2021 | 11:30 | Sivasspor | - | Giresunspor | 0:0 (0:0) | |
| 14:00 | Antalyaspor | - | Altay Izmir | 1:0 (0:0) | ||
| 14:00 | Yeni Malatyaspor | - | İstanbul Başakşehir | 1:3 (0:1) | ||
| 17:00 | Beşiktaş | - | Trabzonspor | 1:2 (0:1) | ||
| 07.11.2021 | 11:30 | Göztepe | - | Konyaspor | 0:2 (0:1) | |
| 14:00 | Adana Demirspor | - | Hatayspor | 1:0 (0:0) | ||
| 14:00 | Fatih Karagümrük SK | - | Galatasaray | 1:1 (0:0) | ||
| 17:00 | Fenerbahçe | - | Kayserispor | 2:2 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Trabzonspor | 12 | 9 | 3 | 0 | 24:11 | 13 | 30 |
| 2 |
|
Hatayspor | 12 | 7 | 2 | 3 | 20:9 | 11 | 23 |
| 3 |
|
Konyaspor | 12 | 6 | 5 | 1 | 18:10 | 8 | 23 |
| 4 |
|
Galatasaray | 12 | 6 | 3 | 3 | 18:15 | 3 | 21 |
| 5 |
|
Alanyaspor | 12 | 6 | 3 | 3 | 18:19 | -1 | 21 |
| 6 |
|
Beşiktaş | 12 | 6 | 2 | 4 | 21:15 | 6 | 20 |
| 7 |
|
Fenerbahçe | 12 | 6 | 2 | 4 | 17:15 | 2 | 20 |
| 8 |
|
Fatih Karagümrük SK | 12 | 5 | 4 | 3 | 18:15 | 3 | 19 |
| 9 |
|
İstanbul Başakşehir | 12 | 6 | 0 | 6 | 18:15 | 3 | 18 |
| 10 |
|
Adana Demirspor | 12 | 4 | 4 | 4 | 17:17 | 0 | 16 |
| 11 |
|
Altay Izmir | 12 | 5 | 1 | 6 | 17:18 | -1 | 16 |
| 12 |
|
Gaziantep FK | 12 | 4 | 3 | 5 | 14:16 | -2 | 15 |
| 13 |
|
Kayserispor | 12 | 4 | 3 | 5 | 17:20 | -3 | 15 |
| 14 |
|
Antalyaspor | 12 | 4 | 3 | 5 | 14:17 | -3 | 15 |
| 15 |
|
Sivasspor | 12 | 2 | 7 | 3 | 15:13 | 2 | 13 |
| 16 |
|
Yeni Malatyaspor | 12 | 4 | 0 | 8 | 12:22 | -10 | 12 |
| 17 |
|
Giresunspor | 12 | 2 | 4 | 6 | 7:12 | -5 | 10 |
| 18 |
|
Kasımpaşa SK | 12 | 2 | 3 | 7 | 12:18 | -6 | 9 |
| 19 |
|
Göztepe | 12 | 2 | 3 | 7 | 11:18 | -7 | 9 |
| 20 |
|
Çaykur Rizespor | 12 | 2 | 1 | 9 | 11:24 | -13 | 7 |
| Champions League | |
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