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| 26.03.2022 | 12:00 | Adıyamanspor | - | Turgutluspor | 2:1 (1:1) | |
| 12:00 | Afjet Afyonspor | - | Sakaryaspor | 2:0 (1:0) | ||
| 12:00 | Ankaraspor | - | Bayburt İl Özel İdare | 0:0 (0:0) | ||
| 12:00 | Bodrumspor | - | Etimesgut Belediyespor | 4:0 (2:0) | ||
| 12:00 | Diyarbekirspor | - | Ergene Velimeşe | 1:0 (1:0) | ||
| 12:00 | 1461 Trabzon FK | - | Sivas Belediyespor | 2:0 (0:0) | ||
| 12:00 | Inegölspor | - | Kahramanmaraşspor | 3:0 (2:0) | ||
| 12:00 | Niğde Anadolu FK | - | Serik Belediyespor | 2:1 (0:1) | ||
| 12:00 | Somaspor | - | Sarıyer SK | 1:1 (0:0) | ||
| 12:00 | Vanspor FK | - | Çorum FK | 1:1 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sakaryaspor | 31 | 20 | 8 | 3 | 60:22 | 38 | 68 |
| 2 |
|
1461 Trabzon FK | 31 | 20 | 7 | 4 | 56:22 | 34 | 67 |
| 3 |
|
Bodrumspor | 31 | 18 | 6 | 7 | 51:23 | 28 | 60 |
| 4 |
|
Vanspor FK | 31 | 15 | 10 | 6 | 44:37 | 7 | 55 |
| 5 |
|
Afjet Afyonspor | 31 | 15 | 8 | 8 | 59:34 | 25 | 53 |
| 6 |
|
Sivas Belediyespor | 31 | 15 | 8 | 8 | 52:28 | 24 | 53 |
| 7 |
|
Somaspor | 31 | 15 | 7 | 9 | 47:39 | 8 | 52 |
| 8 |
|
Çorum FK | 31 | 13 | 10 | 8 | 44:29 | 15 | 49 |
| 9 |
|
Bayburt İl Özel İdare | 31 | 14 | 7 | 10 | 38:30 | 8 | 49 |
| 10 |
|
Inegölspor | 31 | 14 | 6 | 11 | 43:39 | 4 | 48 |
| 11 |
|
Ankaraspor | 31 | 11 | 11 | 9 | 45:34 | 11 | 44 |
| 12 |
|
Etimesgut Belediyespor | 31 | 9 | 9 | 13 | 36:47 | -11 | 36 |
| 13 |
|
Diyarbekirspor | 31 | 10 | 5 | 16 | 29:35 | -6 | 35 |
| 14 |
|
Sarıyer SK | 31 | 8 | 9 | 14 | 35:45 | -10 | 33 |
| 15 |
|
Serik Belediyespor | 31 | 9 | 6 | 16 | 37:48 | -11 | 33 |
| 16 |
|
Adıyamanspor | 31 | 10 | 2 | 19 | 38:57 | -19 | 32 |
| 17 |
|
Turgutluspor | 31 | 6 | 10 | 15 | 26:52 | -26 | 28 |
| 18 |
|
Ergene Velimeşe | 31 | 8 | 3 | 20 | 31:60 | -29 | 27 |
| 19 |
|
Niğde Anadolu FK | 31 | 5 | 5 | 21 | 31:72 | -41 | 20 |
| 20 |
|
Kahramanmaraşspor | 31 | 4 | 5 | 22 | 21:70 | -49 | 17 |
| Promotion | |
| Play-off | |
| Relégation |
