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| 04.03.2022 | 12:30 | Ankaraspor | - | Kahramanmaraşspor | 1:0 (0:0) | |
| 12:30 | Somaspor | - | Sivas Belediyespor | 2:1 (0:1) | ||
| 05.03.2022 | 12:00 | Adıyamanspor | - | Ergene Velimeşe | 0:1 (0:0) | |
| 12:00 | Afjet Afyonspor | - | Diyarbekirspor | 2:0 (0:0) | ||
| 12:00 | Bodrumspor | - | Sarıyer SK | 3:0 (1:0) | ||
| 12:00 | Çorum FK | - | Etimesgut Belediyespor | 3:1 (1:0) | ||
| 12:00 | 1461 Trabzon FK | - | Serik Belediyespor | 5:1 (2:0) | ||
| 12:00 | Inegölspor | - | Turgutluspor | 3:0 (1:0) | ||
| 12:00 | Niğde Anadolu FK | - | Sakaryaspor | 2:3 (1:2) | ||
| 12:00 | Vanspor FK | - | Bayburt İl Özel İdare | 1:1 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sakaryaspor | 29 | 19 | 8 | 2 | 58:20 | 38 | 65 |
| 2 |
|
1461 Trabzon FK | 29 | 18 | 7 | 4 | 51:21 | 30 | 61 |
| 3 |
|
Bodrumspor | 29 | 17 | 5 | 7 | 46:22 | 24 | 56 |
| 4 |
|
Vanspor FK | 29 | 15 | 8 | 6 | 42:35 | 7 | 53 |
| 5 |
|
Afjet Afyonspor | 29 | 14 | 8 | 7 | 56:32 | 24 | 50 |
| 6 |
|
Sivas Belediyespor | 29 | 14 | 8 | 7 | 50:26 | 24 | 50 |
| 7 |
|
Bayburt İl Özel İdare | 29 | 14 | 6 | 9 | 38:29 | 9 | 48 |
| 8 |
|
Somaspor | 29 | 14 | 6 | 9 | 45:38 | 7 | 48 |
| 9 |
|
Çorum FK | 29 | 13 | 8 | 8 | 42:27 | 15 | 47 |
| 10 |
|
Inegölspor | 29 | 13 | 5 | 11 | 39:38 | 1 | 44 |
| 11 |
|
Ankaraspor | 29 | 11 | 10 | 8 | 45:32 | 13 | 43 |
| 12 |
|
Etimesgut Belediyespor | 29 | 9 | 9 | 11 | 36:42 | -6 | 36 |
| 13 |
|
Serik Belediyespor | 29 | 9 | 5 | 15 | 35:45 | -10 | 32 |
| 14 |
|
Sarıyer SK | 29 | 8 | 7 | 14 | 33:43 | -10 | 31 |
| 15 |
|
Diyarbekirspor | 29 | 8 | 5 | 16 | 27:35 | -8 | 29 |
| 16 |
|
Adıyamanspor | 29 | 9 | 2 | 18 | 36:54 | -18 | 29 |
| 17 |
|
Turgutluspor | 29 | 6 | 10 | 13 | 24:47 | -23 | 28 |
| 18 |
|
Ergene Velimeşe | 29 | 7 | 3 | 19 | 29:58 | -29 | 24 |
| 19 |
|
Kahramanmaraşspor | 29 | 4 | 5 | 20 | 20:64 | -44 | 17 |
| 20 |
|
Niğde Anadolu FK | 29 | 3 | 5 | 21 | 26:70 | -44 | 14 |
| Promotion | |
| Play-off | |
| Relégation |
