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| 25.12.2021 | 11:00 | Turgutluspor | - | Kahramanmaraşspor | 0:0 (0:0) | |
| 26.12.2021 | 11:00 | Adıyamanspor | - | Bodrumspor | 3:1 (2:1) | |
| 11:00 | Afjet Afyonspor | - | Çorum FK | 3:1 (2:0) | ||
| 11:00 | Diyarbekirspor | - | Sarıyer SK | 3:1 (1:1) | ||
| 11:00 | Ergene Velimeşe | - | Bayburt İl Özel İdare | 1:2 (1:1) | ||
| 11:00 | Etimesgut Belediyespor | - | Serik Belediyespor | 0:1 (0:1) | ||
| 11:00 | 1461 Trabzon FK | - | Ankaraspor | 2:1 (1:1) | ||
| 11:00 | Inegölspor | - | Somaspor | 0:1 (0:1) | ||
| 11:00 | Niğde Anadolu FK | - | Vanspor FK | 0:1 (0:0) | ||
| 12:00 | Sakaryaspor | - | Sivas Belediyespor | 4:2 (2:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sakaryaspor | 19 | 13 | 6 | 0 | 41:8 | 33 | 45 |
| 2 |
|
1461 Trabzon FK | 19 | 11 | 7 | 1 | 32:14 | 18 | 40 |
| 3 |
|
Afjet Afyonspor | 19 | 10 | 7 | 2 | 40:21 | 19 | 37 |
| 4 |
|
Bayburt İl Özel İdare | 19 | 11 | 3 | 5 | 28:19 | 9 | 36 |
| 5 |
|
Sivas Belediyespor | 19 | 10 | 4 | 5 | 37:18 | 19 | 34 |
| 6 |
|
Çorum FK | 19 | 9 | 7 | 3 | 28:12 | 16 | 34 |
| 7 |
|
Somaspor | 19 | 9 | 5 | 5 | 30:22 | 8 | 32 |
| 8 |
|
Vanspor FK | 19 | 9 | 5 | 5 | 27:25 | 2 | 32 |
| 9 |
|
Bodrumspor | 19 | 9 | 4 | 6 | 30:18 | 12 | 31 |
| 10 |
|
Ankaraspor | 19 | 8 | 6 | 5 | 32:22 | 10 | 30 |
| 11 |
|
Serik Belediyespor | 19 | 9 | 2 | 8 | 27:25 | 2 | 29 |
| 12 |
|
Inegölspor | 19 | 7 | 3 | 9 | 21:27 | -6 | 24 |
| 13 |
|
Diyarbekirspor | 19 | 6 | 4 | 9 | 22:24 | -2 | 22 |
| 14 |
|
Turgutluspor | 19 | 5 | 7 | 7 | 20:30 | -10 | 22 |
| 15 |
|
Etimesgut Belediyespor | 19 | 5 | 6 | 8 | 20:27 | -7 | 21 |
| 16 |
|
Adıyamanspor | 19 | 5 | 1 | 13 | 23:36 | -13 | 16 |
| 17 |
|
Sarıyer SK | 19 | 4 | 3 | 12 | 18:30 | -12 | 15 |
| 18 |
|
Ergene Velimeşe | 19 | 3 | 3 | 13 | 17:41 | -24 | 12 |
| 19 |
|
Kahramanmaraşspor | 19 | 2 | 2 | 15 | 12:51 | -39 | 8 |
| 20 |
|
Niğde Anadolu FK | 19 | 1 | 3 | 15 | 11:46 | -35 | 6 |
| Promotion | |
| Play-off | |
| Relégation |
