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| 16.04.2022 | 14:00 | Pendikspor | - | Şanlıurfaspor | 2:0 (1:0) | |
| 17.04.2022 | 24 Erzincanspor | - | Kastamonuspor | pas disputer | ||
| 12:00 | Isparta 32 SK | - | Pazarspor | 1:0 (1:0) | ||
| 14:00 | 1922 Konyaspor | - | Zonguldak Kömürspor | 0:1 (0:0) | ||
| 14:00 | Akhisar Belediyespor | - | Kırklarelispor | 0:0 (0:0) | ||
| 14:00 | Kırşehir Belediyespor | - | Eskişehirspor | 2:0 (2:0) | ||
| 14:00 | Nazilli Belediyespor | - | Ankara Demirspor | 1:1 (0:0) | ||
| 14:00 | Tarsus Idman Yurdu | - | Amed SK | 2:0 (1:0) | ||
| 14:00 | Uşakspor | - | Karacabey Belediyespor | 0:3 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pendikspor | 31 | 22 | 4 | 5 | 49:23 | 26 | 70 |
| 2 |
|
Tarsus Idman Yurdu | 32 | 15 | 7 | 10 | 40:30 | 10 | 52 |
| 3 |
|
Isparta 32 SK | 32 | 15 | 7 | 10 | 36:27 | 9 | 52 |
| 4 |
|
Amed SK | 31 | 14 | 8 | 9 | 40:34 | 6 | 50 |
| 5 |
|
Karacabey Belediyespor | 31 | 15 | 2 | 14 | 49:39 | 10 | 47 |
| 6 |
|
Bucaspor 1928 | 31 | 13 | 8 | 10 | 47:39 | 8 | 47 |
| 7 |
|
Kırklarelispor | 31 | 11 | 13 | 7 | 37:25 | 12 | 46 |
| 8 |
|
Ankara Demirspor | 32 | 12 | 10 | 10 | 38:32 | 6 | 46 |
| 9 |
|
24 Erzincanspor | 31 | 13 | 6 | 12 | 51:41 | 10 | 45 |
| 10 |
|
Kırşehir Belediyespor | 31 | 10 | 13 | 8 | 35:28 | 7 | 43 |
| 11 |
|
Nazilli Belediyespor | 31 | 10 | 12 | 9 | 30:30 | 0 | 42 |
| 12 |
|
Şanlıurfaspor | 31 | 10 | 10 | 11 | 41:36 | 5 | 40 |
| 13 |
|
Zonguldak Kömürspor | 31 | 9 | 11 | 11 | 34:39 | -5 | 38 |
| 14 |
|
Uşakspor | 31 | 9 | 11 | 11 | 28:41 | -13 | 38 |
| 15 |
|
Pazarspor | 31 | 10 | 2 | 19 | 33:56 | -23 | 32 |
| 16 |
|
Akhisar Belediyespor | 32 | 8 | 6 | 18 | 32:53 | -21 | 30 |
| 17 |
|
1922 Konyaspor | 32 | 6 | 11 | 15 | 36:48 | -12 | 29 |
| 18 |
|
Eskişehirspor | 32 | 6 | 7 | 19 | 28:63 | -35 | 22 |
| 19 |
|
Kastamonuspor | 0 | 0 | 0 | 0 | 0:0 | 0 | 0 |
| Promotion | |
| Play-off | |
| Relégation |
