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| 18.03.2022 | 15:00 | İstanbulspor AŞ | - | Keçiörengücü | 1:1 (1:1) | |
| 19.03.2022 | 11:30 | Ümraniyespor | - | Altınordu FK | 0:1 (0:1) | |
| 14:00 | BB Erzurumspor | - | Samsunspor | 1:2 (0:2) | ||
| 17:00 | Menemen Belediyespor | - | Boluspor | 3:2 (1:0) | ||
| 20.03.2022 | 11:30 | Bandırmaspor | - | Tuzlaspor | 3:1 (1:0) | |
| 11:30 | Manisa FK | - | MKE Ankaragücü | 1:1 (0:0) | ||
| 14:00 | Bursaspor | - | Balıkesirspor | 2:1 (0:1) | ||
| 17:00 | Gençlerbirliği | - | Kocaelispor | 1:1 (0:0) | ||
| 21.03.2022 | 17:00 | Adanaspor | - | Eyüpspor | 1:1 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
MKE Ankaragücü | 28 | 18 | 5 | 5 | 43:20 | 23 | 59 |
| 2 |
|
Ümraniyespor | 28 | 17 | 4 | 7 | 47:27 | 20 | 55 |
| 3 |
|
Bandırmaspor | 28 | 15 | 4 | 9 | 42:25 | 17 | 49 |
| 4 |
|
İstanbulspor AŞ | 27 | 14 | 5 | 8 | 44:30 | 14 | 47 |
| 5 |
|
Eyüpspor | 28 | 12 | 10 | 6 | 41:30 | 11 | 46 |
| 6 |
|
BB Erzurumspor | 28 | 12 | 8 | 8 | 41:33 | 8 | 44 |
| 7 |
|
Samsunspor | 27 | 11 | 9 | 7 | 45:35 | 10 | 42 |
| 8 |
|
Adanaspor | 28 | 10 | 8 | 10 | 32:28 | 4 | 38 |
| 9 |
|
Manisa FK | 28 | 10 | 7 | 11 | 31:34 | -3 | 37 |
| 10 |
|
Boluspor | 27 | 9 | 8 | 10 | 31:31 | 0 | 35 |
| 11 |
|
Keçiörengücü | 27 | 9 | 8 | 10 | 34:36 | -2 | 35 |
| 12 |
|
Menemen Belediyespor | 28 | 8 | 11 | 9 | 36:44 | -8 | 35 |
| 13 |
|
Tuzlaspor | 27 | 9 | 7 | 11 | 24:28 | -4 | 34 |
| 14 |
|
Gençlerbirliği | 27 | 10 | 4 | 13 | 32:42 | -10 | 34 |
| 15 |
|
Kocaelispor | 27 | 9 | 6 | 12 | 26:33 | -7 | 33 |
| 16 |
|
Altınordu FK | 28 | 10 | 1 | 17 | 31:51 | -20 | 31 |
| 17 |
|
Denizlispor | 27 | 8 | 6 | 13 | 26:39 | -13 | 30 |
| 18 |
|
Bursaspor | 27 | 7 | 7 | 13 | 29:40 | -11 | 28 |
| 19 |
|
Balıkesirspor | 27 | 3 | 2 | 22 | 20:49 | -29 | 11 |
| Promotion | |
| Play-off | |
| Relégation |
