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| 26.11.2021 | 15:30 | Balıkesirspor | - | Manisa FK | 0:0 (0:0) | |
| 18:00 | Gençlerbirliği | - | Bursaspor | 2:0 (0:0) | ||
| 27.11.2021 | 11:30 | İstanbulspor AŞ | - | Denizlispor | 1:1 (0:0) | |
| 11:30 | Kocaelispor | - | Menemen Belediyespor | 1:2 (0:1) | ||
| 14:00 | Boluspor | - | Eyüpspor | 3:1 (2:0) | ||
| 17:00 | Samsunspor | - | Adanaspor | 1:0 (0:0) | ||
| 28.11.2021 | 11:30 | Keçiörengücü | - | Ümraniyespor | 3:2 (1:2) | |
| 17:00 | Altınordu FK | - | MKE Ankaragücü | 2:1 (0:0) | ||
| 22.12.2021 | 11:30 | Tuzlaspor | - | BB Erzurumspor | 1:1 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Eyüpspor | 14 | 8 | 3 | 3 | 24:18 | 6 | 27 |
| 2 |
|
MKE Ankaragücü | 14 | 8 | 3 | 3 | 23:11 | 12 | 27 |
| 3 |
|
Ümraniyespor | 13 | 8 | 3 | 2 | 23:10 | 13 | 27 |
| 4 |
|
BB Erzurumspor | 13 | 8 | 2 | 3 | 21:14 | 7 | 26 |
| 5 |
|
Bandırmaspor | 13 | 8 | 1 | 4 | 21:10 | 11 | 25 |
| 6 |
|
Tuzlaspor | 13 | 6 | 3 | 4 | 15:11 | 4 | 21 |
| 7 |
|
İstanbulspor AŞ | 13 | 6 | 2 | 5 | 22:18 | 4 | 20 |
| 8 |
|
Kocaelispor | 13 | 6 | 2 | 5 | 13:14 | -1 | 20 |
| 9 |
|
Samsunspor | 13 | 5 | 4 | 4 | 18:18 | 0 | 19 |
| 10 |
|
Adanaspor | 14 | 5 | 3 | 6 | 16:18 | -2 | 18 |
| 11 |
|
Menemen Belediyespor | 13 | 5 | 2 | 6 | 18:23 | -5 | 17 |
| 12 |
|
Gençlerbirliği | 13 | 5 | 2 | 6 | 14:19 | -5 | 17 |
| 13 |
|
Boluspor | 13 | 4 | 4 | 5 | 16:15 | 1 | 16 |
| 14 |
|
Denizlispor | 13 | 4 | 3 | 6 | 13:18 | -5 | 15 |
| 15 |
|
Bursaspor | 13 | 4 | 2 | 7 | 17:21 | -4 | 14 |
| 16 |
|
Manisa FK | 14 | 4 | 2 | 8 | 15:21 | -6 | 14 |
| 17 |
|
Keçiörengücü | 13 | 4 | 1 | 8 | 14:20 | -6 | 13 |
| 18 |
|
Altınordu FK | 14 | 4 | 1 | 9 | 15:27 | -12 | 13 |
| 19 |
|
Balıkesirspor | 13 | 2 | 1 | 10 | 9:21 | -12 | 7 |
| Promotion | |
| Play-off | |
| Relégation |
