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| 06.03.2022 | 14:00 | Spartak Subotica | - | Partizan | 0:1 (0:0) | |
| 16:15 | Crvena Zvezda | - | FK Novi Pazar | 5:0 (4:0) | ||
| 18:30 | Vojvodina | - | TSC Bačka Topola | 0:1 (0:0) | ||
| 07.03.2022 | 14:00 | FK Radnički 1923 | - | FK Metalac | 1:0 (0:0) | |
| 16:00 | FK Napredak | - | Proleter Novi Sad | 1:1 (0:1) | ||
| 16:00 | Radnik Surdulica | - | FK Čukarički | 0:0 (0:0) | ||
| 18:00 | Radnički Niš | - | FK Kolubara | 1:0 (1:0) | ||
| 08.03.2022 | 16:00 | Mladost Lučani | - | FK Voždovac | 2:4 (1:2) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Partizan | 26 | 23 | 2 | 1 | 64:9 | 55 | 71 |
| 2 |
|
Crvena Zvezda | 26 | 22 | 3 | 1 | 65:14 | 51 | 69 |
| 3 |
|
FK Čukarički | 26 | 13 | 9 | 4 | 44:24 | 20 | 48 |
| 4 |
|
Radnički Niš | 26 | 8 | 12 | 6 | 30:26 | 4 | 36 |
| 5 |
|
Vojvodina | 26 | 10 | 6 | 10 | 33:33 | 0 | 36 |
| 6 |
|
TSC Bačka Topola | 26 | 9 | 7 | 10 | 39:36 | 3 | 34 |
| 7 |
|
FK Voždovac | 26 | 9 | 6 | 11 | 32:33 | -1 | 33 |
| 8 |
|
FK Napredak | 26 | 9 | 6 | 11 | 29:32 | -3 | 33 |
| 9 |
|
FK Kolubara | 26 | 10 | 2 | 14 | 27:47 | -20 | 32 |
| 10 |
|
Radnik Surdulica | 26 | 6 | 12 | 8 | 19:25 | -6 | 30 |
| 11 |
|
Mladost Lučani | 26 | 9 | 3 | 14 | 31:39 | -8 | 30 |
| 12 |
|
Spartak Subotica | 26 | 8 | 6 | 12 | 29:41 | -12 | 30 |
| 13 |
|
Proleter Novi Sad | 26 | 8 | 4 | 14 | 20:42 | -22 | 28 |
| 14 |
|
FK Radnički 1923 | 26 | 7 | 4 | 15 | 23:44 | -21 | 25 |
| 15 |
|
FK Metalac | 26 | 6 | 5 | 15 | 30:46 | -16 | 23 |
| 16 |
|
FK Novi Pazar | 26 | 3 | 9 | 14 | 22:46 | -24 | 18 |
| Play-off | |
| Relégation |
