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| H (Match allé) | FC Voluntari | - | Argeș Pitești | 2:0 (2:0) | ||
| R (match retour) | Argeș Pitești | - | FC Voluntari | 0:1 (0:0) | ||
| H (Match allé): 19.04.2022 19:00 | R (match retour): 11.05.2022 18:30 | vainqueur: FC Voluntari | ||||
| H (Match allé) | Sepsi OSK | - | CS Universitatea Craiova | 2:1 (1:0) | ||
| R (match retour) | CS Universitatea Craiova | - | Sepsi OSK | 0:1 (0:0) | ||
| H (Match allé): 20.04.2022 18:30 | R (match retour): 12.05.2022 18:30 | vainqueur: Sepsi OSK | ||||
