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| 22.04.2022 | 18:00 | Radomiak Radom | - | KS Cracovia | 0:1 (0:1) | |
| 20:30 | Zagłębie Lubin | - | Górnik Zabrze | 2:4 (1:2) | ||
| 23.04.2022 | 15:00 | Śląsk Wrocław | - | Bruk-Bet Termalica Nieciecza | 0:4 (0:3) | |
| 17:30 | Piast Gliwice | - | Jagiellonia Białystok | 2:1 (0:0) | ||
| 20:00 | Lechia Gdańsk | - | Warta Poznań | 2:0 (2:0) | ||
| 24.04.2022 | 12:30 | Lech Poznań | - | FKS Stal Mielec | 3:1 (2:1) | |
| 15:00 | Raków Częstochowa | - | Górnik Łęczna | 2:1 (2:0) | ||
| 17:30 | Pogoń Szczecin | - | Legia Warszawa | 3:1 (1:1) | ||
| 25.04.2022 | 19:00 | Wisła Kraków | - | Wisła Płock | 3:4 (1:3) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Lech Poznań | 30 | 18 | 8 | 4 | 58:21 | 37 | 62 |
| 2 |
|
Pogoń Szczecin | 30 | 18 | 8 | 4 | 59:26 | 33 | 62 |
| 3 |
|
Raków Częstochowa | 30 | 18 | 8 | 4 | 54:27 | 27 | 62 |
| 4 |
|
Lechia Gdańsk | 30 | 15 | 7 | 8 | 47:32 | 15 | 52 |
| 5 |
|
Piast Gliwice | 30 | 13 | 8 | 9 | 39:32 | 7 | 47 |
| 6 |
|
Wisła Płock | 30 | 14 | 3 | 13 | 45:44 | 1 | 45 |
| 7 |
|
Radomiak Radom | 30 | 10 | 13 | 7 | 36:31 | 5 | 43 |
| 8 |
|
KS Cracovia | 30 | 11 | 8 | 11 | 36:38 | -2 | 41 |
| 9 |
|
Górnik Zabrze | 30 | 11 | 7 | 12 | 44:45 | -1 | 40 |
| 10 |
|
Warta Poznań | 30 | 9 | 9 | 12 | 28:33 | -5 | 36 |
| 11 |
|
Legia Warszawa | 30 | 11 | 3 | 16 | 35:41 | -6 | 36 |
| 12 |
|
Jagiellonia Białystok | 30 | 8 | 10 | 12 | 35:47 | -12 | 34 |
| 13 |
|
FKS Stal Mielec | 30 | 8 | 9 | 13 | 34:44 | -10 | 33 |
| 14 |
|
Śląsk Wrocław | 30 | 7 | 11 | 12 | 36:45 | -9 | 32 |
| 15 |
|
Zagłębie Lubin | 30 | 9 | 4 | 17 | 33:54 | -21 | 31 |
| 16 |
|
Wisła Kraków | 30 | 7 | 8 | 15 | 35:49 | -14 | 29 |
| 17 |
|
Bruk-Bet Termalica Nieciecza | 30 | 6 | 9 | 15 | 32:52 | -20 | 27 |
| 18 |
|
Górnik Łęczna | 30 | 6 | 9 | 15 | 26:51 | -25 | 27 |
| Champions League Quali. | |
| Relégation |
