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| 01.10.2010 | 20:00 | AGOVV | - | RBC Roosendaal | 1:0 (0:0) | |
| 20:00 | Go Ahead Eagles | - | FC Dordrecht | 8:0 (4:0) | ||
| 20:00 | Sparta Rotterdam | - | FC Volendam | 1:1 (0:1) | ||
| 20:00 | BV Veendam | - | FC Eindhoven | 1:0 (0:0) | ||
| 20:00 | RKC Waalwijk | - | FC Zwolle | 3:1 (0:1) | ||
| 20:00 | FC Den Bosch | - | FC Emmen | 3:1 (1:1) | ||
| 20:00 | Fortuna Sittard | - | SC Cambuur | 2:1 (1:0) | ||
| 20:00 | Telstar | - | MVV | 1:1 (0:0) | ||
| 20:00 | Helmond Sport | - | Almere City FC | 2:4 (0:3) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
RKC Waalwijk | 8 | 4 | 4 | 0 | 17:9 | 8 | 16 |
| 2 |
|
FC Zwolle | 8 | 5 | 2 | 1 | 14:6 | 8 | 16 |
| 3 |
|
FC Volendam | 8 | 4 | 4 | 0 | 15:9 | 6 | 16 |
| 4 |
|
Sparta Rotterdam | 8 | 4 | 3 | 1 | 26:13 | 13 | 15 |
| 5 |
|
FC Eindhoven | 8 | 4 | 2 | 2 | 12:6 | 6 | 14 |
| 6 |
|
FC Den Bosch | 8 | 4 | 2 | 2 | 19:14 | 5 | 14 |
| 7 |
|
Helmond Sport | 8 | 4 | 2 | 2 | 11:10 | 1 | 14 |
| 8 |
|
Go Ahead Eagles | 8 | 4 | 0 | 4 | 19:10 | 9 | 12 |
| 9 |
|
SC Cambuur | 8 | 4 | 1 | 3 | 13:9 | 4 | 10 |
| 10 |
|
RBC Roosendaal | 8 | 3 | 1 | 4 | 10:9 | 1 | 7 |
| 11 |
|
BV Veendam | 8 | 3 | 2 | 3 | 8:12 | -4 | 7 |
| 12 |
|
Telstar | 8 | 1 | 3 | 4 | 8:14 | -6 | 6 |
| 13 |
|
FC Emmen | 8 | 1 | 2 | 5 | 10:17 | -7 | 5 |
| 14 |
|
MVV | 8 | 2 | 4 | 2 | 10:11 | -1 | 2 |
| 15 |
|
FC Dordrecht | 8 | 2 | 0 | 6 | 9:18 | -9 | 2 |
| 16 |
|
Fortuna Sittard | 8 | 1 | 1 | 6 | 9:21 | -12 | 2 |
| 17 |
|
Almere City FC | 8 | 2 | 1 | 5 | 10:25 | -15 | 1 |
| 18 |
|
AGOVV | 8 | 3 | 0 | 5 | 9:16 | -7 | 0 |
| Promotion | |
| Play-off | |
| Play-off | |
| Relégation |
