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| 13.01.2006 | 20:00 | FC Volendam | - | FC Dordrecht | 1:1 (0:1) | |
| 20:00 | FC Zwolle | - | SBV Excelsior | 0:5 (0:3) | ||
| 20:00 | SC Cambuur | - | AGOVV | 2:3 (2:1) | ||
| 20:00 | De Graafschap | - | BV Veendam | 4:2 (2:0) | ||
| 20:00 | FC Emmen | - | Fortuna Sittard | 2:1 (0:0) | ||
| 20:00 | Helmond Sport | - | VVV-Venlo | 1:1 (0:0) | ||
| 20:00 | FC Omniworld | - | Stormvogels Telstar | 3:1 (2:0) | ||
| 20:00 | MVV | - | FC Eindhoven | 2:0 (0:0) | ||
| 20:00 | TOP Oss | - | Go Ahead Eagles | 1:1 (1:1) | ||
| 15.01.2006 | 14:30 | HFC Haarlem | - | FC Den Bosch | 1:1 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SBV Excelsior | 25 | 16 | 5 | 4 | 52:15 | 37 | 53 |
| 2 |
|
VVV-Venlo | 25 | 15 | 7 | 3 | 39:13 | 26 | 52 |
| 3 |
|
FC Emmen | 25 | 14 | 3 | 8 | 48:31 | 17 | 45 |
| 4 |
|
FC Volendam | 25 | 12 | 7 | 6 | 37:27 | 10 | 43 |
| 5 |
|
FC Den Bosch | 25 | 11 | 9 | 5 | 46:36 | 10 | 42 |
| 6 |
|
Helmond Sport | 25 | 12 | 5 | 8 | 39:38 | 1 | 41 |
| 7 |
|
De Graafschap | 25 | 11 | 6 | 8 | 38:30 | 8 | 39 |
| 8 |
|
FC Zwolle | 25 | 11 | 6 | 8 | 42:35 | 7 | 39 |
| 9 |
|
MVV | 25 | 10 | 8 | 7 | 37:31 | 6 | 38 |
| 10 |
|
FC Dordrecht | 25 | 8 | 9 | 8 | 29:28 | 1 | 33 |
| 11 |
|
AGOVV | 25 | 10 | 3 | 12 | 44:44 | 0 | 33 |
| 12 |
|
BV Veendam | 25 | 9 | 6 | 10 | 36:37 | -1 | 33 |
| 13 |
|
HFC Haarlem | 25 | 9 | 6 | 10 | 35:44 | -9 | 33 |
| 14 |
|
TOP Oss | 25 | 7 | 9 | 9 | 31:40 | -9 | 30 |
| 15 |
|
Go Ahead Eagles | 25 | 6 | 8 | 11 | 30:43 | -13 | 26 |
| 16 |
|
Stormvogels Telstar | 25 | 6 | 8 | 11 | 21:35 | -14 | 26 |
| 17 |
|
FC Omniworld | 25 | 6 | 5 | 14 | 34:56 | -22 | 23 |
| 18 |
|
SC Cambuur | 25 | 5 | 9 | 11 | 26:38 | -12 | 21 |
| 19 |
|
FC Eindhoven | 25 | 5 | 5 | 15 | 33:44 | -11 | 20 |
| 20 |
|
Fortuna Sittard | 25 | 1 | 8 | 16 | 23:55 | -32 | 11 |
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