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| 25.02.2022 | 20:00 | Almere City FC | - | VVV-Venlo | 0:1 (0:1) | |
| 20:00 | De Graafschap | - | FC Den Bosch | 0:0 (0:0) | ||
| 20:00 | FC Dordrecht | - | MVV | 3:1 (0:1) | ||
| 20:00 | SBV Excelsior | - | Roda JC Kerkrade | 2:0 (2:0) | ||
| 20:00 | FC Emmen | - | Jong Ajax | 2:1 (0:1) | ||
| 20:00 | TOP Oss | - | FC Utrecht (J) | 4:1 (4:0) | ||
| 20:00 | FC Volendam | - | Helmond Sport | 4:1 (4:0) | ||
| 20:00 | AZ Alkmaar (J) | - | FC Eindhoven | 1:3 (0:1) | ||
| 20:00 | NAC Breda | - | Jong PSV | 3:1 (1:1) | ||
| 21.03.2022 | 20:00 | ADO Den Haag | - | Telstar | 2:1 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Volendam | 28 | 18 | 8 | 2 | 63:35 | 28 | 62 |
| 2 |
|
FC Emmen | 28 | 18 | 4 | 6 | 45:20 | 25 | 58 |
| 3 |
|
ADO Den Haag | 28 | 18 | 4 | 6 | 59:36 | 23 | 52 |
| 4 |
|
SBV Excelsior | 28 | 16 | 4 | 8 | 60:39 | 21 | 52 |
| 5 |
|
FC Eindhoven | 28 | 15 | 6 | 7 | 51:32 | 19 | 51 |
| 6 |
|
Jong Ajax | 28 | 15 | 4 | 9 | 57:46 | 11 | 49 |
| 7 |
|
Roda JC Kerkrade | 28 | 12 | 10 | 6 | 54:34 | 20 | 46 |
| 8 |
|
De Graafschap | 28 | 13 | 7 | 8 | 40:29 | 11 | 46 |
| 9 |
|
NAC Breda | 28 | 11 | 9 | 8 | 45:33 | 12 | 42 |
| 10 |
|
VVV-Venlo | 28 | 12 | 3 | 13 | 40:38 | 2 | 39 |
| 11 |
|
Jong PSV | 28 | 10 | 5 | 13 | 46:44 | 2 | 35 |
| 12 |
|
TOP Oss | 28 | 8 | 6 | 14 | 35:44 | -9 | 30 |
| 13 |
|
FC Den Bosch | 28 | 9 | 3 | 16 | 30:50 | -20 | 30 |
| 14 |
|
AZ Alkmaar (J) | 28 | 8 | 4 | 16 | 27:39 | -12 | 28 |
| 15 |
|
FC Dordrecht | 28 | 7 | 7 | 14 | 41:59 | -18 | 28 |
| 16 |
|
FC Utrecht (J) | 28 | 8 | 4 | 16 | 30:52 | -22 | 28 |
| 17 |
|
Telstar | 28 | 6 | 10 | 12 | 30:53 | -23 | 28 |
| 18 |
|
MVV | 28 | 8 | 2 | 18 | 29:58 | -29 | 26 |
| 19 |
|
Almere City FC | 28 | 5 | 8 | 15 | 39:57 | -18 | 23 |
| 20 |
|
Helmond Sport | 28 | 6 | 6 | 16 | 27:50 | -23 | 21 |
| Promotion | |
| Play-off | |
| Play-off |
