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| 05.04.2021 | 12:15 | NEC Nijmegen | - | Telstar | 1:1 (1:0) | |
| 14:30 | FC Dordrecht | - | FC Eindhoven | 1:5 (1:2) | ||
| 14:30 | TOP Oss | - | FC Volendam | 2:0 (1:0) | ||
| 14:30 | Helmond Sport | - | Jong Ajax | 1:1 (0:0) | ||
| 14:30 | AZ Alkmaar (J) | - | FC Den Bosch | 2:1 (1:0) | ||
| 14:30 | FC Utrecht (J) | - | De Graafschap | 0:1 (0:1) | ||
| 14:30 | Jong PSV | - | MVV | 3:1 (1:0) | ||
| 14:30 | NAC Breda | - | Go Ahead Eagles | 0:1 (0:1) | ||
| 14:30 | SC Cambuur | - | SBV Excelsior | 7:2 (1:1) | ||
| 16:45 | Roda JC Kerkrade | - | Almere City FC | 0:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Cambuur | 32 | 24 | 4 | 4 | 91:27 | 64 | 76 |
| 2 |
|
De Graafschap | 32 | 21 | 4 | 7 | 60:43 | 17 | 67 |
| 3 |
|
Almere City FC | 32 | 20 | 6 | 6 | 67:40 | 27 | 66 |
| 4 |
|
NAC Breda | 32 | 19 | 6 | 7 | 62:32 | 30 | 63 |
| 5 |
|
Go Ahead Eagles | 32 | 18 | 8 | 6 | 50:22 | 28 | 62 |
| 6 |
|
NEC Nijmegen | 32 | 17 | 6 | 9 | 60:36 | 24 | 57 |
| 7 |
|
FC Volendam | 32 | 14 | 8 | 10 | 64:46 | 18 | 50 |
| 8 |
|
Roda JC Kerkrade | 32 | 13 | 11 | 8 | 58:45 | 13 | 50 |
| 9 |
|
Helmond Sport | 32 | 10 | 10 | 12 | 46:53 | -7 | 40 |
| 10 |
|
Telstar | 32 | 10 | 8 | 14 | 51:49 | 2 | 38 |
| 11 |
|
SBV Excelsior | 32 | 11 | 5 | 16 | 56:60 | -4 | 38 |
| 12 |
|
TOP Oss | 32 | 11 | 5 | 16 | 34:50 | -16 | 38 |
| 13 |
|
MVV | 32 | 11 | 5 | 16 | 40:61 | -21 | 38 |
| 14 |
|
Jong Ajax | 32 | 9 | 9 | 14 | 52:63 | -11 | 36 |
| 15 |
|
Jong PSV | 32 | 9 | 7 | 16 | 49:59 | -10 | 34 |
| 16 |
|
FC Eindhoven | 32 | 8 | 9 | 15 | 43:55 | -12 | 33 |
| 17 |
|
FC Utrecht (J) | 32 | 10 | 1 | 21 | 43:65 | -22 | 31 |
| 18 |
|
AZ Alkmaar (J) | 32 | 8 | 5 | 19 | 44:82 | -38 | 29 |
| 19 |
|
FC Dordrecht | 32 | 8 | 3 | 21 | 33:80 | -47 | 27 |
| 20 |
|
FC Den Bosch | 32 | 5 | 8 | 19 | 38:73 | -35 | 23 |
| Promotion | |
| Play-off |
