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| 15.01.2021 | 18:45 | FC Dordrecht | - | FC Volendam | 0:0 (0:0) | |
| 18:45 | SBV Excelsior | - | FC Eindhoven | 1:0 (1:0) | ||
| 18:45 | Roda JC Kerkrade | - | De Graafschap | 1:3 (0:3) | ||
| 21:00 | Go Ahead Eagles | - | MVV | 3:0 (2:0) | ||
| 21:00 | Helmond Sport | - | FC Den Bosch | 4:0 (3:0) | ||
| 21:00 | AZ Alkmaar (J) | - | Almere City FC | 2:5 (1:4) | ||
| 16.01.2021 | 14:00 | TOP Oss | - | Telstar | 1:4 (0:2) | |
| 17.01.2021 | 12:15 | NEC Nijmegen | - | SC Cambuur | 0:0 (0:0) | |
| 18.01.2021 | 18:45 | FC Utrecht (J) | - | Jong Ajax | 1:2 (0:2) | |
| 21:00 | Jong PSV | - | NAC Breda | 1:1 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Cambuur | 20 | 15 | 2 | 3 | 58:18 | 40 | 47 |
| 2 |
|
Almere City FC | 20 | 14 | 5 | 1 | 47:24 | 23 | 47 |
| 3 |
|
De Graafschap | 20 | 13 | 2 | 5 | 41:29 | 12 | 41 |
| 4 |
|
NAC Breda | 20 | 11 | 4 | 5 | 36:18 | 18 | 37 |
| 5 |
|
Go Ahead Eagles | 20 | 10 | 5 | 5 | 27:15 | 12 | 35 |
| 6 |
|
NEC Nijmegen | 20 | 10 | 5 | 5 | 36:25 | 11 | 35 |
| 7 |
|
FC Volendam | 20 | 9 | 7 | 4 | 44:23 | 21 | 34 |
| 8 |
|
Telstar | 20 | 9 | 4 | 7 | 38:29 | 9 | 31 |
| 9 |
|
FC Eindhoven | 20 | 7 | 6 | 7 | 32:35 | -3 | 27 |
| 10 |
|
Roda JC Kerkrade | 20 | 6 | 8 | 6 | 30:29 | 1 | 26 |
| 11 |
|
Jong Ajax | 20 | 7 | 5 | 8 | 35:38 | -3 | 26 |
| 12 |
|
FC Utrecht (J) | 20 | 8 | 1 | 11 | 31:37 | -6 | 25 |
| 13 |
|
TOP Oss | 20 | 7 | 4 | 9 | 17:28 | -11 | 25 |
| 14 |
|
Helmond Sport | 20 | 6 | 6 | 8 | 28:32 | -4 | 24 |
| 15 |
|
SBV Excelsior | 20 | 7 | 2 | 11 | 35:35 | 0 | 23 |
| 16 |
|
Jong PSV | 20 | 5 | 5 | 10 | 31:39 | -8 | 20 |
| 17 |
|
MVV | 20 | 4 | 4 | 12 | 22:47 | -25 | 16 |
| 18 |
|
AZ Alkmaar (J) | 20 | 4 | 3 | 13 | 27:53 | -26 | 15 |
| 19 |
|
FC Dordrecht | 20 | 3 | 3 | 14 | 18:51 | -33 | 12 |
| 20 |
|
FC Den Bosch | 20 | 2 | 5 | 13 | 19:47 | -28 | 11 |
| Promotion | |
| Play-off |
