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| 26.05.2022 | 14:00 | USV Hercules | - | RKVV Westlandia | 6:3 (2:1) | |
| 14:00 | VV Hoogland | - | Quick Den Haag | 3:0 (1:0) | ||
| 14:00 | HVV Hollandia | - | Unitas Gorinchem | 1:1 (0:1) | ||
| 14:00 | RKVV DEM | - | OSS '20 | 0:0 (0:0) | ||
| 14:00 | JOS Watergraafsmeer | - | EVV | 4:1 (2:1) | ||
| 14:30 | HSC'21 | - | VV UNA | 7:2 (4:1) | ||
| 14:30 | OFC Oostzaan | - | ADO '20 | 0:0 (0:0) | ||
| 19:00 | RKSV Groene Ster | - | Blauw Geel '38 | 1:1 (1:1) | ||
| 02.06.2022 | 19:30 | VV Dongen | - | VV Gemert | 3:3 (1:1) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
OFC Oostzaan | 32 | 17 | 6 | 9 | 62:46 | 16 | 57 |
| 2 |
|
VV Gemert | 32 | 15 | 11 | 6 | 73:54 | 19 | 56 |
| 3 |
|
USV Hercules | 32 | 17 | 4 | 11 | 70:43 | 27 | 55 |
| 4 |
|
ADO '20 | 32 | 16 | 6 | 10 | 57:41 | 16 | 54 |
| 5 |
|
RKSV Groene Ster | 32 | 14 | 9 | 9 | 45:43 | 2 | 51 |
| 6 |
|
OSS '20 | 32 | 14 | 8 | 10 | 55:43 | 12 | 49 |
| 7 |
|
VV UNA | 32 | 15 | 4 | 13 | 58:55 | 3 | 49 |
| 8 |
|
VV Dongen | 32 | 12 | 11 | 9 | 54:45 | 9 | 47 |
| 9 |
|
Quick Den Haag | 32 | 14 | 5 | 13 | 47:40 | 7 | 47 |
| 10 |
|
HSC'21 | 32 | 14 | 4 | 14 | 61:48 | 13 | 46 |
| 11 |
|
Blauw Geel '38 | 32 | 13 | 5 | 14 | 53:52 | 1 | 44 |
| 12 |
|
Unitas Gorinchem | 32 | 12 | 6 | 14 | 40:55 | -15 | 42 |
| 13 |
|
JOS Watergraafsmeer | 32 | 12 | 5 | 15 | 55:63 | -8 | 39 |
| 14 |
|
RKVV DEM | 32 | 11 | 6 | 15 | 33:49 | -16 | 39 |
| 15 |
|
VV Hoogland | 32 | 10 | 5 | 17 | 39:62 | -23 | 35 |
| 16 |
|
HVV Hollandia | 32 | 9 | 5 | 18 | 36:53 | -17 | 32 |
| 17 |
|
EVV | 32 | 7 | 10 | 15 | 33:59 | -26 | 31 |
| 18 |
|
RKVV Westlandia | 32 | 7 | 8 | 17 | 39:59 | -20 | 29 |
| Promotion | |
| Relégation | |
| Relégation |
