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| 01.05.2022 | 14:00 | VV Hoogland | - | OSS '20 | 2:2 (2:1) | |
| 14:00 | VV Dongen | - | VV UNA | 0:1 (0:0) | ||
| 14:00 | HVV Hollandia | - | USV Hercules | 1:3 (1:2) | ||
| 14:00 | Blauw Geel '38 | - | Quick Den Haag | 0:1 (0:0) | ||
| 14:00 | RKVV DEM | - | ADO '20 | 3:2 (3:1) | ||
| 14:00 | Unitas Gorinchem | - | RKVV Westlandia | 1:3 (1:1) | ||
| 14:00 | VV Gemert | - | RKSV Groene Ster | 1:2 (1:0) | ||
| 14:30 | EVV | - | HSC'21 | 1:4 (1:2) | ||
| 14:30 | OFC Oostzaan | - | JOS Watergraafsmeer | 4:0 (3:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VV Gemert | 28 | 15 | 9 | 4 | 65:44 | 21 | 54 |
| 2 |
|
OFC Oostzaan | 28 | 16 | 4 | 8 | 60:45 | 15 | 52 |
| 3 |
|
RKSV Groene Ster | 28 | 14 | 7 | 7 | 43:36 | 7 | 49 |
| 4 |
|
USV Hercules | 28 | 14 | 3 | 11 | 53:37 | 16 | 45 |
| 5 |
|
ADO '20 | 28 | 13 | 5 | 10 | 50:39 | 11 | 44 |
| 6 |
|
OSS '20 | 28 | 13 | 5 | 10 | 52:41 | 11 | 43 |
| 7 |
|
VV Dongen | 28 | 11 | 10 | 7 | 46:36 | 10 | 43 |
| 8 |
|
VV UNA | 28 | 13 | 4 | 11 | 49:43 | 6 | 43 |
| 9 |
|
Quick Den Haag | 28 | 13 | 3 | 12 | 41:34 | 7 | 42 |
| 10 |
|
HSC'21 | 28 | 12 | 3 | 13 | 47:39 | 8 | 39 |
| 11 |
|
Blauw Geel '38 | 28 | 12 | 3 | 13 | 48:42 | 6 | 39 |
| 12 |
|
Unitas Gorinchem | 28 | 11 | 4 | 13 | 35:52 | -17 | 37 |
| 13 |
|
RKVV DEM | 28 | 10 | 5 | 13 | 29:42 | -13 | 35 |
| 14 |
|
JOS Watergraafsmeer | 28 | 10 | 4 | 14 | 45:55 | -10 | 32 |
| 15 |
|
VV Hoogland | 28 | 8 | 5 | 15 | 31:54 | -23 | 29 |
| 16 |
|
EVV | 28 | 6 | 10 | 12 | 28:47 | -19 | 28 |
| 17 |
|
HVV Hollandia | 28 | 8 | 3 | 17 | 30:47 | -17 | 27 |
| 18 |
|
RKVV Westlandia | 28 | 6 | 7 | 15 | 28:47 | -19 | 25 |
| Promotion | |
| Relégation | |
| Relégation |
