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| 20.03.2022 | 14:00 | VV Hoogland | - | RKVV DEM | 0:1 (0:0) | |
| 14:00 | ADO '20 | - | Blauw Geel '38 | 2:1 (0:1) | ||
| 14:00 | VV Dongen | - | RKSV Groene Ster | 2:1 (1:0) | ||
| 14:00 | JOS Watergraafsmeer | - | Quick Den Haag | 1:2 (1:2) | ||
| 14:00 | Unitas Gorinchem | - | VV UNA | 1:4 (1:4) | ||
| 14:00 | VV Gemert | - | RKVV Westlandia | 1:0 (0:0) | ||
| 14:30 | EVV | - | OSS '20 | 1:3 (0:2) | ||
| 14:30 | OFC Oostzaan | - | USV Hercules | 1:2 (1:1) | ||
| 13.04.2022 | 20:00 | HVV Hollandia | - | HSC'21 | 0:4 (0:2) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VV Gemert | 19 | 11 | 7 | 1 | 42:26 | 16 | 40 |
| 2 |
|
OFC Oostzaan | 19 | 13 | 1 | 5 | 43:29 | 14 | 40 |
| 3 |
|
VV UNA | 19 | 10 | 4 | 5 | 36:27 | 9 | 34 |
| 4 |
|
RKSV Groene Ster | 19 | 9 | 6 | 4 | 27:23 | 4 | 33 |
| 5 |
|
ADO '20 | 19 | 10 | 1 | 8 | 34:28 | 6 | 31 |
| 6 |
|
USV Hercules | 19 | 9 | 3 | 7 | 34:26 | 8 | 30 |
| 7 |
|
VV Dongen | 19 | 7 | 8 | 4 | 29:23 | 6 | 29 |
| 8 |
|
OSS '20 | 19 | 9 | 3 | 7 | 33:28 | 5 | 29 |
| 9 |
|
Unitas Gorinchem | 19 | 9 | 2 | 8 | 27:34 | -7 | 29 |
| 10 |
|
Quick Den Haag | 19 | 8 | 2 | 9 | 23:23 | 0 | 26 |
| 11 |
|
JOS Watergraafsmeer | 19 | 8 | 3 | 8 | 38:33 | 5 | 25 |
| 12 |
|
HSC'21 | 19 | 7 | 2 | 10 | 33:29 | 4 | 23 |
| 13 |
|
Blauw Geel '38 | 19 | 6 | 2 | 11 | 30:33 | -3 | 20 |
| 14 |
|
VV Hoogland | 19 | 5 | 4 | 10 | 21:36 | -15 | 19 |
| 15 |
|
RKVV Westlandia | 19 | 4 | 6 | 9 | 21:26 | -5 | 18 |
| 16 |
|
HVV Hollandia | 19 | 5 | 3 | 11 | 16:29 | -13 | 18 |
| 17 |
|
EVV | 19 | 3 | 8 | 8 | 14:27 | -13 | 17 |
| 18 |
|
RKVV DEM | 19 | 4 | 3 | 12 | 12:33 | -21 | 15 |
| Promotion | |
| Relégation | |
| Relégation |
