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| 06.03.2022 | 14:00 | VV Dongen | - | RKVV Westlandia | 0:0 (0:0) | |
| 14:00 | HVV Hollandia | - | Quick Den Haag | 2:0 (1:0) | ||
| 14:00 | Unitas Gorinchem | - | RKSV Groene Ster | 1:1 (0:0) | ||
| 14:00 | VV Gemert | - | HSC'21 | 3:1 (1:1) | ||
| 14:30 | OFC Oostzaan | - | OSS '20 | 1:0 (1:0) | ||
| 14:30 | VV UNA | - | RKVV DEM | 3:0 (1:0) | ||
| 16.03.2022 | 20:00 | ADO '20 | - | VV Hoogland | 3:0 (2:0) | |
| 20:00 | Blauw Geel '38 | - | USV Hercules | 0:1 (0:1) | ||
| 30.03.2022 | 20:00 | EVV | - | JOS Watergraafsmeer | 0:4 (0:3) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
OFC Oostzaan | 17 | 13 | 1 | 3 | 41:23 | 18 | 40 |
| 2 |
|
VV Gemert | 17 | 9 | 7 | 1 | 39:25 | 14 | 34 |
| 3 |
|
VV UNA | 17 | 9 | 3 | 5 | 31:25 | 6 | 30 |
| 4 |
|
RKSV Groene Ster | 17 | 8 | 6 | 3 | 25:21 | 4 | 30 |
| 5 |
|
Unitas Gorinchem | 17 | 9 | 2 | 6 | 26:27 | -1 | 29 |
| 6 |
|
ADO '20 | 17 | 9 | 1 | 7 | 32:26 | 6 | 28 |
| 7 |
|
USV Hercules | 17 | 8 | 3 | 6 | 31:23 | 8 | 27 |
| 8 |
|
VV Dongen | 17 | 6 | 8 | 3 | 24:18 | 6 | 26 |
| 9 |
|
OSS '20 | 17 | 8 | 2 | 7 | 29:26 | 3 | 25 |
| 10 |
|
JOS Watergraafsmeer | 17 | 7 | 3 | 7 | 36:31 | 5 | 22 |
| 11 |
|
Blauw Geel '38 | 17 | 6 | 2 | 9 | 29:30 | -1 | 20 |
| 12 |
|
Quick Den Haag | 17 | 6 | 2 | 9 | 18:22 | -4 | 20 |
| 13 |
|
HVV Hollandia | 17 | 5 | 3 | 9 | 16:22 | -6 | 18 |
| 14 |
|
HSC'21 | 17 | 5 | 2 | 10 | 25:26 | -1 | 17 |
| 15 |
|
VV Hoogland | 17 | 4 | 4 | 9 | 17:34 | -17 | 16 |
| 16 |
|
RKVV Westlandia | 17 | 3 | 6 | 8 | 18:25 | -7 | 15 |
| 17 |
|
EVV | 17 | 2 | 8 | 7 | 12:24 | -12 | 14 |
| 18 |
|
RKVV DEM | 17 | 3 | 3 | 11 | 11:32 | -21 | 12 |
| Promotion | |
| Relégation | |
| Relégation |
