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| 20.02.2022 | 14:00 | USV Hercules | - | Quick Den Haag | 1:3 (1:1) | |
| 14:00 | ADO '20 | - | RKVV DEM | 2:0 (2:0) | ||
| 14:00 | Blauw Geel '38 | - | RKSV Groene Ster | 1:1 (1:1) | ||
| 14:00 | RKVV Westlandia | - | HSC'21 | 1:0 (0:0) | ||
| 14:00 | Unitas Gorinchem | - | HVV Hollandia | 0:3 (0:1) | ||
| 14:00 | VV Gemert | - | JOS Watergraafsmeer | 4:3 (1:0) | ||
| 14:30 | OSS '20 | - | VV Hoogland | 4:1 (2:0) | ||
| 14:30 | OFC Oostzaan | - | EVV | 2:0 (1:0) | ||
| 14:30 | VV UNA | - | VV Dongen | 1:1 (0:1) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
OFC Oostzaan | 15 | 12 | 1 | 2 | 36:18 | 18 | 37 |
| 2 |
|
VV Gemert | 15 | 8 | 6 | 1 | 34:22 | 12 | 30 |
| 3 |
|
VV UNA | 15 | 8 | 2 | 5 | 26:23 | 3 | 26 |
| 4 |
|
RKSV Groene Ster | 15 | 7 | 5 | 3 | 22:19 | 3 | 26 |
| 5 |
|
ADO '20 | 15 | 8 | 1 | 6 | 28:23 | 5 | 25 |
| 6 |
|
Unitas Gorinchem | 15 | 8 | 1 | 6 | 23:25 | -2 | 25 |
| 7 |
|
USV Hercules | 15 | 7 | 3 | 5 | 29:21 | 8 | 24 |
| 8 |
|
VV Dongen | 15 | 5 | 7 | 3 | 22:18 | 4 | 22 |
| 9 |
|
OSS '20 | 15 | 7 | 2 | 6 | 27:24 | 3 | 22 |
| 10 |
|
Blauw Geel '38 | 15 | 6 | 2 | 7 | 27:26 | 1 | 20 |
| 11 |
|
Quick Den Haag | 15 | 5 | 2 | 8 | 15:18 | -3 | 17 |
| 12 |
|
JOS Watergraafsmeer | 15 | 5 | 3 | 7 | 27:27 | 0 | 16 |
| 13 |
|
HVV Hollandia | 15 | 4 | 3 | 8 | 14:20 | -6 | 15 |
| 14 |
|
VV Hoogland | 15 | 4 | 3 | 8 | 15:29 | -14 | 15 |
| 15 |
|
HSC'21 | 15 | 4 | 2 | 9 | 21:22 | -1 | 14 |
| 16 |
|
RKVV Westlandia | 15 | 3 | 5 | 7 | 17:23 | -6 | 14 |
| 17 |
|
EVV | 15 | 2 | 7 | 6 | 10:18 | -8 | 13 |
| 18 |
|
RKVV DEM | 15 | 3 | 3 | 9 | 10:27 | -17 | 12 |
| Promotion | |
| Relégation | |
| Relégation |
