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| 14.11.2021 | 14:00 | VV Hoogland | - | Blauw Geel '38 | 2:1 (0:0) | |
| 14:00 | VV Dongen | - | USV Hercules | 2:2 (1:2) | ||
| 14:00 | HVV Hollandia | - | RKVV Westlandia | 2:0 (0:0) | ||
| 14:00 | RKVV DEM | - | Quick Den Haag | 2:2 (0:0) | ||
| 14:00 | JOS Watergraafsmeer | - | ADO '20 | 1:3 (1:1) | ||
| 14:00 | VV Gemert | - | OSS '20 | 2:1 (0:0) | ||
| 14:30 | HSC'21 | - | RKSV Groene Ster | 0:1 (0:0) | ||
| 14:30 | EVV | - | Unitas Gorinchem | 1:2 (0:1) | ||
| 14:30 | OFC Oostzaan | - | VV UNA | 2:0 (2:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
OFC Oostzaan | 12 | 10 | 1 | 1 | 27:13 | 14 | 31 |
| 2 |
|
VV Gemert | 12 | 7 | 5 | 0 | 29:15 | 14 | 26 |
| 3 |
|
Unitas Gorinchem | 12 | 7 | 1 | 4 | 19:17 | 2 | 22 |
| 4 |
|
VV UNA | 12 | 7 | 0 | 5 | 24:22 | 2 | 21 |
| 5 |
|
RKSV Groene Ster | 12 | 5 | 4 | 3 | 17:17 | 0 | 19 |
| 6 |
|
USV Hercules | 12 | 5 | 3 | 4 | 24:17 | 7 | 18 |
| 7 |
|
OSS '20 | 12 | 6 | 1 | 5 | 22:18 | 4 | 18 |
| 8 |
|
ADO '20 | 12 | 6 | 0 | 6 | 23:21 | 2 | 18 |
| 9 |
|
VV Dongen | 12 | 4 | 5 | 3 | 18:16 | 2 | 17 |
| 10 |
|
JOS Watergraafsmeer | 12 | 5 | 2 | 5 | 21:18 | 3 | 15 |
| 11 |
|
VV Hoogland | 12 | 4 | 3 | 5 | 12:20 | -8 | 15 |
| 12 |
|
Blauw Geel '38 | 12 | 4 | 1 | 7 | 19:23 | -4 | 13 |
| 13 |
|
EVV | 12 | 2 | 6 | 4 | 8:13 | -5 | 12 |
| 14 |
|
HVV Hollandia | 12 | 3 | 3 | 6 | 11:17 | -6 | 12 |
| 15 |
|
HSC'21 | 12 | 3 | 2 | 7 | 17:20 | -3 | 11 |
| 16 |
|
Quick Den Haag | 12 | 3 | 2 | 7 | 11:16 | -5 | 11 |
| 17 |
|
RKVV Westlandia | 12 | 2 | 4 | 6 | 14:19 | -5 | 10 |
| 18 |
|
RKVV DEM | 12 | 2 | 3 | 7 | 7:21 | -14 | 9 |
| Promotion | |
| Relégation | |
| Relégation |
