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| 14.05.2022 | 14:30 | VVOG Harderwijk | - | Harkemase Boys | 2:3 (1:0) | |
| 14:30 | AFC Ajax Zaterdag | - | HSV Hoek | 3:0 (1:0) | ||
| 14:30 | VV Staphorst | - | ACV Assen | 1:3 (0:2) | ||
| 14:30 | Excelsior '31 | - | Sparta Nijkerk | 0:4 (0:1) | ||
| 14:30 | VV GOES | - | ODIN '59 | 1:0 (1:0) | ||
| 14:30 | BVV Barendrecht | - | VV DOVO Veenendaal | 3:1 (1:0) | ||
| 14:30 | DVS'33 | - | Ter Leede | 1:1 (0:1) | ||
| 15:00 | Sportlust '46 | - | FC Lisse | 0:2 (0:0) | ||
| 18:00 | VV Sint Bavo | - | SteDoCo | 2:0 (0:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Lisse | 30 | 19 | 5 | 6 | 60:34 | 26 | 62 |
| 2 |
|
Sparta Nijkerk | 30 | 16 | 7 | 7 | 57:32 | 25 | 55 |
| 3 |
|
Sportlust '46 | 30 | 16 | 6 | 8 | 56:35 | 21 | 54 |
| 4 |
|
BVV Barendrecht | 30 | 12 | 11 | 7 | 65:47 | 18 | 47 |
| 5 |
|
DVS'33 | 30 | 14 | 4 | 12 | 50:37 | 13 | 46 |
| 6 |
|
Excelsior '31 | 30 | 13 | 7 | 10 | 48:43 | 5 | 46 |
| 7 |
|
HSV Hoek | 30 | 13 | 7 | 10 | 44:44 | 0 | 46 |
| 8 |
|
ACV Assen | 30 | 12 | 8 | 10 | 42:35 | 7 | 44 |
| 9 |
|
VV Staphorst | 30 | 12 | 6 | 12 | 45:45 | 0 | 42 |
| 10 |
|
Harkemase Boys | 30 | 10 | 10 | 10 | 56:51 | 5 | 40 |
| 11 |
|
SteDoCo | 30 | 11 | 6 | 13 | 46:47 | -1 | 39 |
| 12 |
|
Ter Leede | 30 | 11 | 5 | 14 | 38:54 | -16 | 38 |
| 13 |
|
VV Sint Bavo | 30 | 10 | 6 | 14 | 46:55 | -9 | 36 |
| 14 |
|
ODIN '59 | 30 | 9 | 7 | 14 | 44:58 | -14 | 34 |
| 15 |
|
AFC Ajax Zaterdag | 30 | 9 | 5 | 16 | 34:49 | -15 | 32 |
| 16 |
|
VVOG Harderwijk | 30 | 8 | 7 | 15 | 52:73 | -21 | 31 |
| 17 |
|
VV DOVO Veenendaal | 30 | 7 | 8 | 15 | 34:53 | -19 | 29 |
| 18 |
|
VV GOES | 30 | 6 | 9 | 15 | 42:67 | -25 | 27 |
| Promotion | |
| Relégation | |
| Relégation |
