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| 29.04.2022 | 20:00 | VV GOES | - | HSV Hoek | 0:1 (0:0) | |
| 30.04.2022 | 14:30 | AFC Ajax Zaterdag | - | ACV Assen | 0:2 (0:0) | |
| 14:30 | VV Staphorst | - | SteDoCo | 2:0 (0:0) | ||
| 14:30 | FC Lisse | - | Sparta Nijkerk | 4:2 (0:1) | ||
| 14:30 | BVV Barendrecht | - | VV Sint Bavo | 6:0 (3:0) | ||
| 14:30 | DVS'33 | - | Harkemase Boys | 1:0 (0:0) | ||
| 14:30 | Ter Leede | - | Excelsior '31 | 2:1 (1:0) | ||
| 15:00 | Sportlust '46 | - | VVOG Harderwijk | 4:0 (4:0) | ||
| 15:00 | VV DOVO Veenendaal | - | ODIN '59 | 2:1 (0:1) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Lisse | 28 | 17 | 5 | 6 | 56:34 | 22 | 56 |
| 2 |
|
Sportlust '46 | 28 | 15 | 6 | 7 | 52:33 | 19 | 51 |
| 3 |
|
Sparta Nijkerk | 28 | 14 | 7 | 7 | 47:30 | 17 | 49 |
| 4 |
|
Excelsior '31 | 28 | 13 | 7 | 8 | 48:37 | 11 | 46 |
| 5 |
|
HSV Hoek | 28 | 13 | 7 | 8 | 44:37 | 7 | 46 |
| 6 |
|
BVV Barendrecht | 28 | 11 | 10 | 7 | 60:44 | 16 | 43 |
| 7 |
|
DVS'33 | 28 | 13 | 3 | 12 | 46:35 | 11 | 42 |
| 8 |
|
VV Staphorst | 28 | 12 | 6 | 10 | 43:40 | 3 | 42 |
| 9 |
|
ACV Assen | 28 | 11 | 8 | 9 | 38:31 | 7 | 41 |
| 10 |
|
SteDoCo | 28 | 11 | 5 | 12 | 44:43 | 1 | 38 |
| 11 |
|
Ter Leede | 28 | 11 | 4 | 13 | 36:50 | -14 | 37 |
| 12 |
|
Harkemase Boys | 28 | 8 | 10 | 10 | 51:49 | 2 | 34 |
| 13 |
|
ODIN '59 | 28 | 8 | 7 | 13 | 41:55 | -14 | 31 |
| 14 |
|
VVOG Harderwijk | 28 | 8 | 7 | 13 | 50:68 | -18 | 31 |
| 15 |
|
VV Sint Bavo | 28 | 8 | 6 | 14 | 42:54 | -12 | 30 |
| 16 |
|
AFC Ajax Zaterdag | 28 | 8 | 5 | 15 | 29:46 | -17 | 29 |
| 17 |
|
VV DOVO Veenendaal | 28 | 6 | 8 | 14 | 30:49 | -19 | 26 |
| 18 |
|
VV GOES | 28 | 5 | 9 | 14 | 39:61 | -22 | 24 |
| Promotion | |
| Relégation | |
| Relégation |
