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| 14.04.2022 | 20:00 | Harkemase Boys | - | VV DOVO Veenendaal | 1:0 (1:0) | |
| 16.04.2022 | 14:30 | VVOG Harderwijk | - | AFC Ajax Zaterdag | 1:1 (1:0) | |
| 14:30 | HSV Hoek | - | VV Staphorst | 3:1 (2:0) | ||
| 14:30 | Excelsior '31 | - | VV GOES | 3:3 (2:0) | ||
| 14:30 | ACV Assen | - | FC Lisse | 0:1 (0:0) | ||
| 14:30 | ODIN '59 | - | Sparta Nijkerk | 1:1 (0:0) | ||
| 14:30 | BVV Barendrecht | - | Sportlust '46 | 2:1 (0:1) | ||
| 14:30 | SteDoCo | - | Ter Leede | 3:1 (1:1) | ||
| 15:00 | VV Sint Bavo | - | DVS'33 | 3:2 (1:2) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Lisse | 25 | 15 | 4 | 6 | 48:29 | 19 | 49 |
| 2 |
|
Sparta Nijkerk | 25 | 14 | 6 | 5 | 43:23 | 20 | 48 |
| 3 |
|
Sportlust '46 | 25 | 12 | 6 | 7 | 46:33 | 13 | 42 |
| 4 |
|
BVV Barendrecht | 25 | 10 | 10 | 5 | 52:36 | 16 | 40 |
| 5 |
|
Excelsior '31 | 25 | 11 | 7 | 7 | 43:34 | 9 | 40 |
| 6 |
|
HSV Hoek | 25 | 11 | 7 | 7 | 38:32 | 6 | 40 |
| 7 |
|
SteDoCo | 25 | 11 | 5 | 9 | 43:37 | 6 | 38 |
| 8 |
|
DVS'33 | 25 | 11 | 3 | 11 | 41:31 | 10 | 36 |
| 9 |
|
VV Staphorst | 25 | 10 | 6 | 9 | 36:35 | 1 | 36 |
| 10 |
|
ACV Assen | 25 | 9 | 7 | 9 | 30:28 | 2 | 34 |
| 11 |
|
Ter Leede | 25 | 10 | 4 | 11 | 31:41 | -10 | 34 |
| 12 |
|
Harkemase Boys | 25 | 7 | 9 | 9 | 43:44 | -1 | 30 |
| 13 |
|
AFC Ajax Zaterdag | 25 | 8 | 5 | 12 | 29:41 | -12 | 29 |
| 14 |
|
VVOG Harderwijk | 25 | 7 | 7 | 11 | 45:59 | -14 | 28 |
| 15 |
|
VV Sint Bavo | 25 | 7 | 6 | 12 | 40:47 | -7 | 27 |
| 16 |
|
ODIN '59 | 25 | 7 | 6 | 12 | 33:49 | -16 | 27 |
| 17 |
|
VV DOVO Veenendaal | 25 | 4 | 8 | 13 | 24:44 | -20 | 20 |
| 18 |
|
VV GOES | 25 | 4 | 8 | 13 | 32:54 | -22 | 20 |
| Promotion | |
| Relégation | |
| Relégation |
