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| 02.04.2022 | 14:30 | HSV Hoek | - | ACV Assen | 1:1 (1:0) | |
| 14:30 | VV Staphorst | - | Sparta Nijkerk | 2:0 (1:0) | ||
| 14:30 | Excelsior '31 | - | VVOG Harderwijk | 2:1 (0:1) | ||
| 14:30 | BVV Barendrecht | - | FC Lisse | 6:2 (2:2) | ||
| 14:30 | DVS'33 | - | VV DOVO Veenendaal | 3:0 (2:0) | ||
| 14:30 | SteDoCo | - | ODIN '59 | 2:0 (1:0) | ||
| 14:30 | Ter Leede | - | AFC Ajax Zaterdag | 2:1 (1:1) | ||
| 15:00 | Sportlust '46 | - | VV GOES | 3:0 (1:0) | ||
| 15:30 | VV Sint Bavo | - | Harkemase Boys | 4:1 (0:1) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sparta Nijkerk | 23 | 14 | 5 | 4 | 41:20 | 21 | 47 |
| 2 |
|
FC Lisse | 23 | 14 | 3 | 6 | 47:29 | 18 | 45 |
| 3 |
|
Sportlust '46 | 23 | 12 | 5 | 6 | 45:31 | 14 | 41 |
| 4 |
|
Excelsior '31 | 23 | 11 | 5 | 7 | 40:31 | 9 | 38 |
| 5 |
|
BVV Barendrecht | 23 | 9 | 10 | 4 | 48:32 | 16 | 37 |
| 6 |
|
HSV Hoek | 23 | 10 | 7 | 6 | 35:27 | 8 | 37 |
| 7 |
|
VV Staphorst | 23 | 10 | 5 | 8 | 35:32 | 3 | 35 |
| 8 |
|
Ter Leede | 23 | 10 | 4 | 9 | 29:36 | -7 | 34 |
| 9 |
|
DVS'33 | 23 | 10 | 3 | 10 | 35:28 | 7 | 33 |
| 10 |
|
SteDoCo | 23 | 9 | 5 | 9 | 38:35 | 3 | 32 |
| 11 |
|
ACV Assen | 23 | 8 | 7 | 8 | 28:26 | 2 | 31 |
| 12 |
|
AFC Ajax Zaterdag | 23 | 8 | 3 | 12 | 27:39 | -12 | 27 |
| 13 |
|
Harkemase Boys | 23 | 6 | 8 | 9 | 41:43 | -2 | 26 |
| 14 |
|
ODIN '59 | 23 | 7 | 5 | 11 | 31:46 | -15 | 26 |
| 15 |
|
VVOG Harderwijk | 23 | 6 | 6 | 11 | 42:57 | -15 | 24 |
| 16 |
|
VV Sint Bavo | 23 | 6 | 5 | 12 | 34:42 | -8 | 23 |
| 17 |
|
VV DOVO Veenendaal | 23 | 4 | 7 | 12 | 21:40 | -19 | 19 |
| 18 |
|
VV GOES | 23 | 3 | 7 | 13 | 26:49 | -23 | 16 |
| Promotion | |
| Relégation | |
| Relégation |
