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| 22.03.2022 | 20:00 | HSV Hoek | - | Sparta Nijkerk | 0:0 (0:0) | |
| 20:00 | VV Staphorst | - | AFC Ajax Zaterdag | 1:0 (0:0) | ||
| 20:00 | BVV Barendrecht | - | Harkemase Boys | 0:0 (0:0) | ||
| 20:00 | DVS'33 | - | VV GOES | 5:1 (3:0) | ||
| 20:00 | SteDoCo | - | VVOG Harderwijk | 1:4 (1:2) | ||
| 20:00 | Sportlust '46 | - | ACV Assen | 0:0 (0:0) | ||
| 20:00 | Ter Leede | - | ODIN '59 | 2:0 (1:0) | ||
| 20:00 | VV DOVO Veenendaal | - | FC Lisse | 0:0 (0:0) | ||
| 12.04.2022 | 20:00 | VV Sint Bavo | - | Excelsior '31 | 4:2 (1:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sparta Nijkerk | 21 | 13 | 5 | 3 | 38:18 | 20 | 44 |
| 2 |
|
FC Lisse | 21 | 13 | 3 | 5 | 44:23 | 21 | 42 |
| 3 |
|
Sportlust '46 | 21 | 11 | 5 | 5 | 41:29 | 12 | 38 |
| 4 |
|
Excelsior '31 | 21 | 10 | 4 | 7 | 38:30 | 8 | 34 |
| 5 |
|
BVV Barendrecht | 21 | 8 | 9 | 4 | 42:30 | 12 | 33 |
| 6 |
|
HSV Hoek | 21 | 9 | 6 | 6 | 32:26 | 6 | 33 |
| 7 |
|
Ter Leede | 21 | 9 | 4 | 8 | 27:32 | -5 | 31 |
| 8 |
|
DVS'33 | 21 | 9 | 3 | 9 | 32:27 | 5 | 30 |
| 9 |
|
VV Staphorst | 21 | 8 | 5 | 8 | 32:32 | 0 | 29 |
| 10 |
|
ACV Assen | 21 | 7 | 6 | 8 | 24:25 | -1 | 27 |
| 11 |
|
Harkemase Boys | 21 | 6 | 8 | 7 | 39:37 | 2 | 26 |
| 12 |
|
SteDoCo | 21 | 7 | 5 | 9 | 34:34 | 0 | 26 |
| 13 |
|
ODIN '59 | 21 | 7 | 5 | 9 | 31:42 | -11 | 26 |
| 14 |
|
AFC Ajax Zaterdag | 21 | 7 | 3 | 11 | 24:36 | -12 | 24 |
| 15 |
|
VVOG Harderwijk | 21 | 5 | 6 | 10 | 37:52 | -15 | 21 |
| 16 |
|
VV Sint Bavo | 21 | 5 | 5 | 11 | 27:37 | -10 | 20 |
| 17 |
|
VV DOVO Veenendaal | 21 | 4 | 7 | 10 | 21:34 | -13 | 19 |
| 18 |
|
VV GOES | 21 | 3 | 7 | 11 | 26:45 | -19 | 16 |
| Promotion | |
| Relégation | |
| Relégation |
