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| 26.09.2021 | 15:00 | FK Borec | - | FK Skopje | 0:2 (0:2) | |
| 15:00 | FK Rabotnički | - | FK Pelister | 1:1 (1:0) | ||
| 15:00 | FK Renova | - | FK Bregalnica Štip | 5:2 (3:1) | ||
| 15:00 | FC Struga | - | KF Shkëndija 79 | 1:1 (1:0) | ||
| 15:00 | GFK Tikvesh | - | Makedonija GP | 3:0 (0:0) | ||
| 18:00 | Akademija Pandev | - | KF Shkupi | 1:3 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 8 | 5 | 2 | 1 | 16:6 | 10 | 17 |
| 2 |
|
FK Renova | 8 | 5 | 2 | 1 | 15:7 | 8 | 17 |
| 3 |
|
FK Rabotnički | 8 | 4 | 3 | 1 | 9:5 | 4 | 15 |
| 4 |
|
Akademija Pandev | 8 | 4 | 2 | 2 | 14:9 | 5 | 14 |
| 5 |
|
FC Struga | 8 | 3 | 4 | 1 | 9:6 | 3 | 13 |
| 6 |
|
KF Shkëndija 79 | 8 | 2 | 5 | 1 | 13:8 | 5 | 11 |
| 7 |
|
FK Bregalnica Štip | 8 | 2 | 4 | 2 | 11:13 | -2 | 10 |
| 8 |
|
Makedonija GP | 8 | 3 | 0 | 5 | 10:18 | -8 | 9 |
| 9 |
|
FK Skopje | 8 | 2 | 2 | 4 | 6:13 | -7 | 8 |
| 10 |
|
FK Borec | 8 | 2 | 1 | 5 | 7:14 | -7 | 7 |
| 11 |
|
GFK Tikvesh | 8 | 1 | 2 | 5 | 6:11 | -5 | 5 |
| 12 |
|
FK Pelister | 8 | 0 | 3 | 5 | 4:10 | -6 | 3 |
| Champions League Quali. | |
| Relégation | |
| Relégation |
