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| 22.08.2021 | 16:00 | FK Borec | - | FK Bregalnica Štip | 1:1 (0:0) | |
| 16:00 | FK Rabotnički | - | GFK Tikvesh | 2:1 (1:0) | ||
| 16:00 | FK Skopje | - | FK Pelister | 1:0 (1:0) | ||
| 16:00 | KF Shkëndija 79 | - | Makedonija GP | 4:0 (1:0) | ||
| 16:00 | FC Struga | - | KF Shkupi | 4:2 (3:1) | ||
| 20:00 | Akademija Pandev | - | FK Renova | 2:1 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Akademija Pandev | 4 | 3 | 1 | 0 | 7:2 | 5 | 10 |
| 2 |
|
FC Struga | 4 | 2 | 2 | 0 | 6:3 | 3 | 8 |
| 3 |
|
FK Renova | 4 | 2 | 1 | 1 | 6:4 | 2 | 7 |
|
KF Shkupi | 4 | 2 | 1 | 1 | 6:4 | 2 | 7 | |
| 5 |
|
FK Rabotnički | 4 | 2 | 1 | 1 | 3:3 | 0 | 7 |
| 6 |
|
Makedonija GP | 4 | 2 | 0 | 2 | 6:7 | -1 | 6 |
| 7 |
|
KF Shkëndija 79 | 4 | 1 | 2 | 1 | 8:5 | 3 | 5 |
| 8 |
|
FK Skopje | 4 | 1 | 2 | 1 | 3:6 | -3 | 5 |
| 9 |
|
FK Bregalnica Štip | 4 | 0 | 4 | 0 | 4:4 | 0 | 4 |
| 10 |
|
FK Borec | 4 | 1 | 1 | 2 | 3:5 | -2 | 4 |
| 11 |
|
GFK Tikvesh | 4 | 0 | 1 | 3 | 2:6 | -4 | 1 |
| 12 |
|
FK Pelister | 4 | 0 | 0 | 4 | 0:5 | -5 | 0 |
| Champions League Quali. | |
| Relégation | |
| Relégation |
