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| 09.05.2021 | 16:00 | FK Belasica | - | Akademija Pandev | 0:2 (0:2) | |
| 16:00 | FK Borec | - | FK Renova | 2:0 (1:0) | ||
| 16:00 | FK Rabotnički | - | Sileks Kratovo | 3:1 (1:1) | ||
| 16:00 | KF Shkupi | - | FK Pelister | 0:0 (0:0) | ||
| 16:00 | Makedonija GP | - | KF Shkëndija 79 | 3:4 (2:2) | ||
| 16:00 | FC Struga | - | Vardar Skopje | 1:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkëndija 79 | 32 | 22 | 8 | 2 | 68:25 | 43 | 74 |
| 2 |
|
KF Shkupi | 32 | 16 | 10 | 6 | 40:23 | 17 | 58 |
| 3 |
|
FC Struga | 32 | 14 | 12 | 6 | 38:24 | 14 | 54 |
| 4 |
|
Makedonija GP | 32 | 15 | 7 | 10 | 51:43 | 8 | 52 |
| 5 |
|
FK Rabotnički | 32 | 11 | 14 | 7 | 44:38 | 6 | 47 |
| 6 |
|
FK Pelister | 32 | 11 | 9 | 12 | 32:38 | -6 | 42 |
| 7 |
|
FK Borec | 32 | 11 | 7 | 14 | 31:33 | -2 | 40 |
| 8 |
|
Akademija Pandev | 32 | 11 | 5 | 16 | 29:35 | -6 | 38 |
| 9 |
|
Sileks Kratovo | 32 | 10 | 6 | 16 | 49:44 | 5 | 36 |
| 10 |
|
FK Renova | 32 | 8 | 11 | 13 | 35:45 | -10 | 35 |
| 11 |
|
Vardar Skopje | 32 | 7 | 10 | 15 | 32:58 | -26 | 31 |
| 12 |
|
FK Belasica | 32 | 4 | 5 | 23 | 23:66 | -43 | 17 |
| Champions League Quali. | |
| Relégation | |
| Relégation |
