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| H (Match allé) | Club Tijuana | - | CF América | 1:0 (0:0) | ||
| R (match retour) | CF América | - | Club Tijuana | 1:0 (0:0) | ||
| H (Match allé): 12.05.2022 04:00 | R (match retour): 14.05.2022 16:00 | |||||
| H (Match allé) | UANL Tigres | - | Club León | 1:0 (1:0) | ||
| R (match retour) | Club León | - | UANL Tigres | 3:3 (1:1) | ||
| H (Match allé): 12.05.2022 18:00 | R (match retour): 15.05.2022 16:00 | vainqueur: UANL Tigres | ||||
