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| H (Match allé) | Santos Laguna | - | Atlas Guadalajara | 1:1 (1:1) | ||
| R (match retour) | Atlas Guadalajara | - | Santos Laguna | 1:1 (0:1) | ||
| H (Match allé): 12.05.2021 16:00 | R (match retour): 15.05.2021 16:00 | |||||
| H (Match allé) | Deportivo Guadalajara | - | CF Pachuca | 2:2 (0:0) | ||
| R (match retour) | CF Pachuca | - | Deportivo Guadalajara | 1:2 (0:1) | ||
| H (Match allé): 12.05.2021 17:00 | R (match retour): 16.05.2021 00:00 | vainqueur: Deportivo Guadalajara | ||||
