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| 16.07.2022 | 16:00 | Deportivo Toluca | - | CF Pachuca | 3:0 (2:0) | |
| 16:00 | Cruz Azul | - | CF América | 2:3 (0:2) | ||
| 16:00 | Gallos Blancos | - | FC Juárez | 1:0 (1:0) | ||
| 16:00 | Atlético San Luis | - | Santos Laguna | 3:2 (2:1) | ||
| 16:00 | Club Necaxa | - | Pumas UNAM | 3:0 (2:0) | ||
| 16:00 | CF Monterrey | - | Atlas Guadalajara | 3:1 (3:0) | ||
| 16:00 | Deportivo Guadalajara | - | Club León | 4:2 (2:0) | ||
| 19:00 | Club Tijuana | - | UANL Tigres | 2:0 (2:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| 1 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Pachuca | 4 | 3 | 0 | 1 | 7:6 | 1 | 9 |
| 2 |
|
Club Necaxa | 3 | 2 | 1 | 0 | 13:4 | 9 | 7 |
| 3 |
|
FC Juárez | 4 | 1 | 2 | 1 | 5:5 | 0 | 5 |
| 4 |
|
Pumas UNAM | 4 | 1 | 2 | 1 | 3:5 | -2 | 5 |
| 5 |
|
Deportivo Toluca | 3 | 1 | 1 | 1 | 8:6 | 2 | 4 |
| 6 |
|
CF América | 3 | 1 | 1 | 1 | 5:5 | 0 | 4 |
| 7 |
|
Gallos Blancos | 4 | 1 | 1 | 2 | 3:9 | -6 | 4 |
| 8 |
|
Cruz Azul | 4 | 0 | 2 | 2 | 6:8 | -2 | 2 |
| 9 |
|
Puebla FC | 3 | 0 | 2 | 1 | 4:6 | -2 | 2 |
| 2 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 4 | 3 | 0 | 1 | 9:5 | 4 | 9 |
| 2 |
|
Santos Laguna | 4 | 3 | 0 | 1 | 8:5 | 3 | 9 |
| 3 |
|
Mazatlán FC | 3 | 2 | 1 | 0 | 5:3 | 2 | 7 |
| 4 |
|
CF Monterrey | 4 | 2 | 0 | 2 | 7:7 | 0 | 6 |
| 5 |
|
Atlas Guadalajara | 4 | 2 | 0 | 2 | 4:5 | -1 | 6 |
| 6 |
|
Club Tijuana | 4 | 1 | 1 | 2 | 3:3 | 0 | 4 |
| 7 |
|
Atlético San Luis | 3 | 1 | 0 | 2 | 6:7 | -1 | 3 |
| 8 |
|
UANL Tigres | 3 | 1 | 0 | 2 | 2:5 | -3 | 3 |
| 9 |
|
Club León | 3 | 0 | 0 | 3 | 2:6 | -4 | 0 |
| Play-off | |
| Play-off |
