 |
 |
| 20.11.2021 | 16:00 | UANL Tigres | - | Deportivo Guadalajara | 2:2 (0:0) | |
| 17:00 | FC Juárez | - | CF América | 2:0 (0:0) | ||
| 18:00 | CF Pachuca | - | Gallos Blancos | 2:4 (0:3) | ||
| 18:30 | Club León | - | Santos Laguna | 0:1 (0:1) | ||
| 19:00 | Club Tijuana | - | Cruz Azul | 0:0 (0:0) | ||
| 19:00 | Club Necaxa | - | CF Monterrey | 1:1 (0:0) | ||
| 19:00 | Puebla FC | - | Pumas UNAM | 1:3 (0:2) | ||
| 23:00 | Atlético San Luis | - | Atlas Guadalajara | 2:1 (2:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 16 | 11 | 4 | 1 | 49:17 | 32 | 37 |
| 2 |
|
Deportivo Toluca | 16 | 10 | 5 | 1 | 30:15 | 15 | 35 |
| 3 |
|
Pumas UNAM | 16 | 10 | 3 | 3 | 27:14 | 13 | 33 |
| 4 |
|
Santos Laguna | 16 | 9 | 4 | 3 | 30:19 | 11 | 31 |
| 5 |
|
UANL Tigres | 16 | 8 | 4 | 4 | 29:19 | 10 | 28 |
| 6 |
|
CF Pachuca | 16 | 8 | 3 | 5 | 22:20 | 2 | 27 |
| 7 |
|
Cruz Azul | 16 | 7 | 4 | 5 | 18:17 | 1 | 25 |
| 8 |
|
Club León | 16 | 7 | 3 | 6 | 24:21 | 3 | 24 |
| 9 |
|
Club Tijuana | 16 | 7 | 3 | 6 | 20:21 | -1 | 24 |
| 10 |
|
Club Necaxa | 16 | 6 | 3 | 7 | 23:19 | 4 | 21 |
| 11 |
|
CF Monterrey | 16 | 5 | 5 | 6 | 22:28 | -6 | 20 |
| 12 |
|
Atlas Guadalajara | 16 | 6 | 1 | 9 | 33:33 | 0 | 19 |
| 13 |
|
Puebla FC | 16 | 5 | 4 | 7 | 25:28 | -3 | 19 |
| 14 |
|
Mazatlán FC | 16 | 5 | 1 | 10 | 25:47 | -22 | 16 |
| 15 |
|
Gallos Blancos | 16 | 3 | 5 | 8 | 21:24 | -3 | 14 |
| 16 |
|
CF América | 16 | 4 | 2 | 10 | 20:27 | -7 | 14 |
| 17 |
|
FC Juárez | 16 | 2 | 3 | 11 | 13:30 | -17 | 9 |
| 18 |
|
Atlético San Luis | 16 | 2 | 1 | 13 | 13:45 | -32 | 7 |
| Play-off |
