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| 20.08.2022 | 18:00 | Puebla FC | - | Pumas UNAM | 1:2 (1:0) | |
| 18:15 | Deportivo Guadalajara | - | Mazatlán FC | 4:1 (3:0) | ||
| 19:45 | CF América | - | CF Pachuca | 2:2 (2:1) | ||
| 21:45 | Club Tijuana | - | Atlético San Luis | 6:3 (4:1) | ||
| 06.09.2022 | 18:00 | UANL Tigres | - | Atlas Guadalajara | 1:0 (1:0) | |
| 07.09.2022 | 19:00 | Gallos Blancos | - | Deportivo Toluca | 3:1 (2:1) | |
| 21.09.2022 | 18:30 | Club León | - | Santos Laguna | 4:1 (3:1) | |
| 28.09.2022 | 18:30 | Cruz Azul | - | Club Necaxa | 0:2 (0:2) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| 1 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pumas UNAM | 8 | 7 | 1 | 0 | 19:10 | 9 | 22 |
| 2 |
|
Club Necaxa | 8 | 5 | 0 | 3 | 16:5 | 11 | 15 |
| 3 |
|
Deportivo Toluca | 8 | 4 | 3 | 1 | 17:12 | 5 | 15 |
| 4 |
|
CF Pachuca | 8 | 3 | 3 | 2 | 11:7 | 4 | 12 |
| 5 |
|
Gallos Blancos | 8 | 3 | 2 | 3 | 14:10 | 4 | 11 |
| 6 |
|
Cruz Azul | 8 | 3 | 1 | 4 | 16:18 | -2 | 10 |
| 7 |
|
CF América | 8 | 2 | 2 | 4 | 12:17 | -5 | 8 |
| 8 |
|
Puebla FC | 8 | 2 | 0 | 6 | 10:17 | -7 | 6 |
| 9 |
|
FC Juárez | 8 | 1 | 0 | 7 | 11:30 | -19 | 3 |
| 2 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Tijuana | 8 | 6 | 1 | 1 | 25:9 | 16 | 19 |
| 2 |
|
CF Monterrey | 8 | 5 | 3 | 0 | 22:10 | 12 | 18 |
| 3 |
|
Atlas Guadalajara | 8 | 4 | 3 | 1 | 21:8 | 13 | 15 |
| 4 |
|
Deportivo Guadalajara | 8 | 4 | 0 | 4 | 11:11 | 0 | 12 |
| 5 |
|
UANL Tigres | 8 | 3 | 2 | 3 | 12:17 | -5 | 11 |
| 6 |
|
Club León | 8 | 3 | 1 | 4 | 12:11 | 1 | 10 |
| 7 |
|
Santos Laguna | 8 | 2 | 2 | 4 | 20:18 | 2 | 8 |
| 8 |
|
Atlético San Luis | 8 | 2 | 0 | 6 | 11:34 | -23 | 6 |
| 9 |
|
Mazatlán FC | 8 | 1 | 0 | 7 | 9:25 | -16 | 3 |
| Play-off | |
| Play-off |
