 |
 |
|
|
| 16.10.2021 | 00:00 | Gallos Blancos | - | Deportivo Toluca | 0:1 (0:0) | |
| 19:00 | Cruz Azul | - | Mazatlán FC | 2:0 (1:0) | ||
| 17.10.2021 | 19:00 | Puebla FC | - | Atlético San Luis | 1:1 (0:1) | |
| 19.10.2021 | 00:00 | Club Necaxa | - | CF Monterrey | 1:6 (0:4) | |
| 02:00 | CF América | - | Club Tijuana | 2:0 (0:0) | ||
| 02:00 | Club León | - | Atlas Guadalajara | 0:1 (0:0) | ||
| 04:00 | Deportivo Guadalajara | - | UANL Tigres | 1:1 (0:1) | ||
| 04:00 | FC Juárez | - | CF Pachuca | 1:3 (0:2) | ||
| 04:00 | Santos Laguna | - | Pumas UNAM | 2:0 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UANL Tigres | 13 | 12 | 1 | 0 | 44:5 | 39 | 37 |
| 2 |
|
CF Monterrey | 13 | 10 | 2 | 1 | 32:8 | 24 | 32 |
| 3 |
|
Deportivo Guadalajara | 13 | 9 | 2 | 2 | 29:12 | 17 | 29 |
| 4 |
|
Santos Laguna | 13 | 8 | 3 | 2 | 32:15 | 17 | 27 |
| 5 |
|
CF América | 13 | 8 | 3 | 2 | 25:11 | 14 | 27 |
| 6 |
|
Atlas Guadalajara | 13 | 7 | 3 | 3 | 18:13 | 5 | 24 |
| 7 |
|
Club Tijuana | 13 | 5 | 3 | 5 | 15:15 | 0 | 18 |
| 8 |
|
Cruz Azul | 13 | 5 | 3 | 5 | 11:18 | -7 | 18 |
| 9 |
|
Pumas UNAM | 13 | 3 | 6 | 4 | 12:13 | -1 | 15 |
| 10 |
|
Deportivo Toluca | 13 | 4 | 3 | 6 | 12:18 | -6 | 15 |
| 11 |
|
CF Pachuca | 13 | 3 | 5 | 5 | 18:21 | -3 | 14 |
| 12 |
|
Club Necaxa | 13 | 4 | 2 | 7 | 11:29 | -18 | 14 |
| 13 |
|
Puebla FC | 13 | 3 | 2 | 8 | 14:24 | -10 | 11 |
| 14 |
|
Atlético San Luis | 13 | 2 | 5 | 6 | 12:25 | -13 | 11 |
| 15 |
|
Gallos Blancos | 13 | 2 | 4 | 7 | 12:17 | -5 | 10 |
| 16 |
|
Club León | 13 | 2 | 4 | 7 | 13:23 | -10 | 10 |
| 17 |
|
Mazatlán FC | 13 | 1 | 3 | 9 | 6:27 | -21 | 6 |
| 18 |
|
FC Juárez | 13 | 1 | 2 | 10 | 7:29 | -22 | 5 |
| Play-off |
