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| H (Match allé) | Motagua | - | Marathón | 1:2 (0:0) | ||
| R (match retour) | Marathón | - | Motagua | 0:0 (0:0) | ||
| H (Match allé): 04.05.2023 02:00 | R (match retour): 07.05.2023 23:30 | vainqueur: Marathón | ||||
| H (Match allé) | Lobos UPNFM | - | Real España | 0:0 (0:0) | ||
| R (match retour) | Real España | - | Lobos UPNFM | 2:0 (1:0) | ||
| H (Match allé): 05.05.2023 02:00 | R (match retour): 08.05.2023 02:00 | vainqueur: Real España | ||||
